Short-term exercise training does not change PAI-1 levels in normal, asymptomatic men and women. In addition, modest decreases in insulin and triglyceride in individuals with elevated body fatness do not result in changes in PAI-1 after short-term training. It appears likely that decreases in PAI-1 with exercise training require decreases in adiposity and/or marked changes in metabolic variables.
RESUMO -Nas amostras de líqüido cefalorraqueano (LCR) de 200 pacientes com afecções do sistema nervoso central (SNC) foi efetuada pesquisa de anticorpos a Trypanosama cruzi (T. cruzi) mediante: reação de fixação do complemento (RFC) em 69, reação de imunofluorescência (IgG) indireta (RIF) em 118, ambas em 13. Em 50 casos, para a RIF, o LCR foi também previamente concentrado 20 vezes. Os resultados foram avaliados em relação às patologias que acometiam o SNC, ao comportamento das células e proteínas do LCR e ao resultado de investigações imunológicas no LCR para outras infecções do SNC (sífilis, cisticercose, esquistossomíase e toxoplasmose) para as quais técnicas semelhantes foram adotadas. Anticorpos a T. cruzi foram demonstrados em três pacientes: em um com reagudização da moléstia de Chagas na vigência da síndrome de imunodeficiência adquirida; em um paciente com epilepsia e em um paciente com acidente vascular cerebral, ambos com moléstia de Chagas comprovada pela presença de anticorpos a T. cruzi no soro. These tests were based on techniques similar to those adopted for the search of antibodies to T. cruzi, and were conducted concomitantly to tests for T. cruzi in the same CSF sample for everyone of the cases. Antibodies to T. cruzi were found in three patients.
Antibodies toThe first was a patient committed by the acquired immunodeficiency syndrome (AIDS) in whom there occurred exacerbation of the acute stage of Chagas' disease.The second is a patient who is committed by epilepsy, and an acute stroke occurred in the third patient; Chagas' disease had been previously diagnosed in them through the demonstration of antibodies to T. cruzi in the blood serum.Limitam-se as possibilidades diagnosticas de acometimento do sistema nervoso central (SNC) na forma crônica da doença de Chagas, à associação: manifestações clínicas compatíveis ao tipo de lesão encefálica comumente provocado pelo Trypanosoma cruzi (T. cruzi); presença de anticorpos ao parasita no soro do paciente. A vigência desse binômio aventa, assim, a possibilidade de diagnóstico provável.
K E Y W O R D S : H T L V -I , myelopathy, neuroepidemiology, geographical distribution.Reflexões sobre H A M / T S P : redescobrindo Tumaco. The chance discovery of an agent has given rise to an etiopathogenic discussion revolving around a nosological entity in some instances, in Medicine. This was the case in 1984 concerning tropical spastic paraparesis (TSP). The finding in two patients with TSP of seropositivity for HTLV-I 2 , a retrovirus originally associated to acute T-cell leukemia (ATL)?. Since then, it is considered to have the «status» of the putative causal agent of this myelopathy. Seroepidemiological studies followed this event in TSP geographical foci previously defined that proved the significant association between TSP and HTLV-I 5,10,21,28,32,38. And, as from the identity verified between this myelopathy and those associated to HTLV-I (HAM) from Japan, both condtions began to be known together as HAM/TSP 30. The perspective opened by the possibility of the etiopathogenic
RESUMO -São feitas considerações acerca do papel etiopatogênico do H T L V -I na paraplegia espástica tropical ( T S P ) , a mielopatia associada ao H T D V -I ( H A M ) . Aspectos neuroepide-
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