Even though no survival benefit was identified between the cases and controls the increased incidence of metachronous colorectal cancer and increased abdominal surgeries among controls warrant the recommendation of subtotal colectomy in patients with Lynch syndrome.
blinatumomab may be seen in the settings of both MRD and also active ALL. These data support phase I/II studies with XmAb-5574 in adult ALL.
CONFLICT OF INTERESTThe authors declare no conflict of interest.
ACKNOWLEDGEMENTSWe thank the patients for providing research samples used in this study and members of the CLL Experimental Therapeutics laboratory for critical comments. We are grateful for research support from The Leukemia and Lymphoma Society, P50-CA140158, PO1-CA95426, The Harry Mangurian Foundation, and The D Warren Brown Foundation. XENP-5603 and XmAb-5574 were provided by Xencor, Inc.
AUTHOR CONTRIBUTIONSSR designed and performed experiments, wrote the first draft of the manuscript, contributed to revisions of the paper, and approved the final submitted version. CC provided input into experimental design, performed experiments, and reviewed and approved the final version of the manuscript. DJ and XM assisted in design of experiments, performed the statistical analysis reported, reviewed and approved the final version of the manuscript. NM and JCB obtained funding to perform the research, designed the experiments, participated in the analysis of the data, reviewed multiple drafts of the manuscript and approved the final version for submission.
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