Synthesis and Antitumor Activity of New Sulfonamide Derivatives of Thiadiazolo[3,2-a]pyrimidines. -A variety of new 2-sulfonamidothiadiazolepyrimidines is synthesized starting from 2-aminothiadiazole-5-sulfonamide (I) and evaluated for antitumor activities in vitro and in vivo. Derivatives (IIIb), (IIIc) and (IIIf) exhibit the highest affinity to DNA and show the highest percentage increase in lifespan of mice inoculated with Ehrlich ascites cells over 5-flurouracil as positive control. -(EL-SAYED, N. S.; EL-BENDARY*, E. R.; EL-ASHRY, S. M.; EL-KERDAWY, M. M.; Eur. J. Med. Chem. 46 (2011) 9, 3714-3720, http://dx.
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