Peach is a medicinal plant which has many traditional applications uses against various diseases. In this study we have evaluated differences in tannins and flavonoids in the composition of flowers and peach leaves and their antioxidant properties. Antibacterial activity of the peach flower and leaf extract was investigated using Mycobacterium tuberculosis and E. coli by the disk diffusion method. Total fractions of flavonoids and tannins were obtained using ethanol and aqueous extraction, respectively. The antioxidant activity was evaluated using the adrenaline autooxidation test. The results have shown that the peach flower extract contains many flavonoids, tannins that probably account for better antimicrobial effects as compared with the peach leaf extract. This shows perspectives for the use of peach flowers for the treatment of many diseases, especially for tuberculosis, and other diseases associated with overproduction of free radicals.
Quantum chemical calculations of energies, electronic structures, and molecular geome tries of 3,5,6 trimethylthieno[2,3 d]pyrimidin 4 one (1), tricyclic 2,3 tri , 2,3 tetra , and 2,3 pentamethylene substituted 5,6 dimethylthieno[2,3 d]pyrimidin 4 ones (2-4), carboxy lic acids 5-8 resulting from oxidation of compounds 1-4 at the methyl group in position 5 of thienopyrimidine, methyl esters of these acids (9-12), and products of ipso nitration of esters (13-16) were performed in terms of the HF and DFT (B3LYP) approximations with the 3 21G basis set. Also, calculations for mixed anhydrides of nitric acid and carboxylic acids 17-20 were carried out. The possible causes of differences in the behaviors of 3 unsubstituted and 3 substituted thieno[2,3 d]pyrimidin 4 ones were discussed.Key words: thieno[2,3 d]pyrimidin 4 ones, nitric acid oxidation, ipso substitution, quan tum chemical calculations, Hartree-Fock method (HF), DFT/B3LYP 3 21G method.
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