In the current research, attempt is made to fabricate a nanoemulsion (NE) containing an antifungal agent. The prepared formulation has been expected to enhance skin penetration. It is also studied for in vitro drug release and toxicity assessment. Spontaneous titration method was used for preparation of NE. Prepared NE were characterized for their charge, size, morphology, rheological behaviour, drug release profile, skin permeability. The drug permeation and skin irritation were investigated. The in vitro antifungal activity was inspected using the well agar diffusion method. Miconazole NE showed good penetration in the skin as compared to marketed products. SEM showed semispherical shapes of the droplets. Zeta potential and zeta sizer showed that size was in nano ranges having positive charge.
Juzam (leprosy) is attributed to excessive accumulation, infiltration and dispersal of sauda (burnt humours) throughout the body disturbing the normal temperament of the organs. A variety of causative factors responsible for excessive production or retention of sauda are enumerated. Unani simple plants, animals and minerals and formulations used for the treatment of leprosy are tabulated with recipes, methods of preparation, does and modes of administration.
Background: Transradial artery is being utilized by an expanding number of interventional cardiologists to perform percutaneous interventions. Nevertheless, occlusion of radial artery (RAO) is prominent after transradial (TR) catheterization. The use of anticoagulant drugs is one way to prevent RAO. The use of high-dose heparin and standard-dose heparin is still debatable. The present study will analyze the non-randomized controlled trials of standard and high doses of heparin for the prevention of radial artery occlusion after transradial catheterization.
Methodology: A prospective double-blinded non-randomized controlled trial was carried out. Demographic data on socio-economic statuses, such as age, occupation, gender, and smoking habits, were collected. Grouping was done so that patients may either be placed in group 1, which will receive 2500UI or into group 2, which will get 5000UI of unfractionated heparin. RAO was the critical endpoint of our study. Major bleeding, hematomas, and radial artery spasms were secondary outcome measures.
Results: 471 patients were made part of this study. 235 patients were placed in group A which received 2500IU, and 236 were placed in group B, which received 5000IU. RAO was noted to be significantly higher in the group that received the standard dose of UFH as compared to the group that received a high dose of UFH (8 % vs. 3.3 %, p = 0.005). Female gender (OR: 2.951, 95% CI: 1.57-5.46, p = 0.002), hypertension (OR: 0.02, 95% CI: p = 0.005 and standard dose UFH (OR: 2.822, 95% CI: 1.343 – 5.911, p =. 0.007) were found to be the independent predictors of RAO.
Conclusion: Weight-adjusted higher dosage of UFH in TRA for diagnosis yielded remarkable results in reducing the rates of early RAO against the standard administered dosage.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.