Imaging based sensitive clinical diagnosis is critically depending on image quality. In this article, the problem of enhancing fundus images is addressed by a novel fusion technique. The proposed approach utilizes the representation capability of wavelet transform and the learning ability of artificial neural networks. In this approach, input images are decomposed into wavelet transform followed by appropriate feature extraction for training of neural networks to obtain fused image. To ensure homogeneity, it employs consistency verification for minimizing the fusion artifacts. The visual and quantitative performance of the proposed approach is assessed using a number of experiments performed on the standard datasets of DRIVE and DRION‐DB. The experimental results demonstrate that the proposed fusion technique offers high average structural similarity of “0.99.” The proposed approach outperforms state‐of‐the‐art techniques which validates its effectiveness. The developed approach might be applied by the clinical diagnosis system for fundus related diseases.
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