Background: Overhand pitching is a movement that requires the coordination of lower extremity, trunk, and upper extremity segments to effectively transfer force throughout the kinetic chain to project a baseball. Objective: The purpose of this study was to investigate the effect of cardiorespiratory fatigue on throwing ball velocity related to kinematics motion changes in baseball. Methods: The study samples included 12 male baseball athletes (19.3 ± 2.8 years old, height of 1.71.4 ± 3.1 m, and weight of 64.3 ± 3.6 kg). A descriptive quantitative method approach was used. The instruments included two high-resolution handycams (Sony HXR-MC2500, Japan), a high-speed camera (Fastec Imaging TS5-H, USA), a radar speed gun (Bushnell 101922, Germany), a 3D force platform (The AMTI Optima Series 20210, USA), 14 point manual markers, a motion capture system software (Frame DIAZ IV, Japan), and a heart rate sensor (Polar H10, Finland). Results: The results of this study showed that there were significant differences in the ball velocity (p= 0.042), stride length percentage height (p= 0.041), elbow flexion (p= 0.046), maximum shoulder horizontal adduction (p= 0.041), maximum elbow extension angular velocity (p= 0.035), maximum shoulder internal rotation (p= 0.029), and lateral trunk tilt (p= 0.029) when the pitchers were fatigued. Conclusion: Cardiorespiratory fatigue causes changes in the kinetic harmonization of upper and lower body motion, which results in a decrease in the ball velocity. These results are similar to those in previous studies conducted with the intervention of muscle fatigue during overhead baseball throwing, which causes a decrease in the performance and ball velocity.
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