Introduction: Diabetes mellitus (DM) is considered one of the largest emerging threats to health and bacterial infections are more frequent in diabetic patients causing sepsis. Several indicators have been proposed as new diagnostic tests to assess sepsis in hospitalized patients. Aim: This study aims was to compare the efficacy of Procalcitonin (PCT) and high sensitive C-reactive protein (hs-CRP) in the diagnosis of sepsis in diabetic patients. Methods: In this cross-sectional study total of 60 age and sex-matched diabetic patients above 18 years were randomly chosen with at least 2 SIRS (Systemic inflammatory response syndrome) criteria from the indoor department of BIRDEM General Hospital. Basic hematological, biochemical, microbiological laboratory data were recorded from laboratory reports. Sepsis and its different stages were determined according to American College of Chest Physicians (ACCP) guidelines. The PCT was measured by sandwich enzyme immunoassay (Bio-Vendor, Germany) and the hs-CRP level was measured using an immune-turbidimetric assay (Beckman, Carlsbad, CA 92010, USA). Results: The patient’s mean age was 51.90±9.89 years where male 51.2% and female 48.8% and 50-60 years age group was the most common 40%. 38 (63.33%) patients were bacteriological culture-positive and 22 (36.67%) patients were bacteriological culture-negative where the most common organism was Klebsiella (28.95%). Statistically, a significant difference was found in PCT values in the bacteriological culture positive and negative group (p<0.05), but there was no significant difference found in hs-CRP values (p>0.05). There was an increasing trend of serum PCT with the developing stages of sepsis. Receiver operating characteristic curve shows the area under the curve for PCT was 0.785 (95% CI; 0.654-0.915), sensitivity 89.47%, specificity 50%, PPV 75.55% and NPV 73.33% with the best cut-off value >753pg/ml which support PCT as a superior and reliable marker of sepsis. Conclusion: Our results suggest that serum PCT is a more reliable diagnostic marker of sepsis than other traditional markers like hs-CRP. Combinatorial use of these biomarkers will help in early diagnosis and also greatly improve outcomes. Bangladesh Crit Care J March 2022; 10 (1): 38-42
Identifying the relationship between demographical factors with COVID-19 infection could demonstrate some prevention strategies of “possible super-spreaders”.To evaluate the correlation between recovery and demographic characteristics of COVID-19-infected patientsA descriptive type of study to demonstrate the 200 COVID-19 infections with various demographical variables by using a questionnaire. The survey consisted of 64-close ended queries, including a short summary of the study background, purpose, procedures, privacy contract, and knowledgeable consent form.For statistical analysis Independent T-test or ANOVA test and SPSS version 25 (IBM, USA) and STATA 15 were used.The male-female ratio of COVID-19 infected patients is 115:100. 50% of patients have never attended social gatherings before getting COVID-19 infection. Social events were visited by 44% of the participants. 47.24% need hospitalization during the positive period, whereas 52.76% recovered at home. Respondents older than 40 years required oxygen support for recovery (p< 0.05). The most common symptoms were loss of smell and taste (53%), headache (48%) body pain (38%), and, fever (33%) in the first-time infection however, these symptoms decreased by Second- and third-time re-infection. Similarly, 20% of patients need oxygen support the first time of infection; it decreased by 10% the second time and 4% the third time. There is a statistically significant difference in the mean recovery time between the people from different professions (p< 0.05). The recovery time of COVID-19 infections is associated with age, profession, and the number of COVID-19 infection times.
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