Vibrations can be used to convey positional or sensory information to prosthetic users. However, for the feedback to convey information consistently, daily fine-grained adjustments are required. This paper investigates whether vibration dissipation through the muscle can be tracked using EMG with the aim of providing reliable long-term sensory feedback. The results of this study showed that the magnitude of vibration artifacts can be measured using EMG and used to create a dissipation trend. This trend varies between participants but shows consistency when measured across multiple days. This novel way of measuring vibration dissipation can potentially be used as a basis of adaptive sensory control in future prosthesis studies.
Purpose
This paper presents an assessment of a low-cost organ perfusion machine designed for use in research settings. The machine is modular and versatile in nature, built on a robotic operating system (ROS2) pipeline allowing for the addition of specific sensors for different research applications. Here we present the system and the development stages to achieve viability of the perfused organ.
Methods
The machine’s perfusion efficacy was assessed by monitoring the distribution of perfusate in livers using methylene blue dye. Functionality was evaluated by measuring bile production after 90 min of normothermic perfusion, while viability was examined using aspartate transaminase assays to monitor cell damage throughout the perfusion. Additionally, the output of the pressure, flow, temperature, and oxygen sensors was monitored and recorded to track the health of the organ during perfusion and assess the system’s capability of maintaining the quality of data over time.
Results
The results show the system is capable of successfully perfusing porcine livers for up to three hours. Functionality and viability assessments show no deterioration of liver cells once normothermic perfusion had occurred and bile production was within normal limits of approximately 26 ml in 90 min showing viability.
Conclusion
The developed low-cost perfusion system presented here has been shown to keep porcine livers viable and functional ex vivo. Additionally, the system is capable of easily incorporating several sensors into its framework and simultaneously monitor and record them during perfusion. The work promotes further exploration of the system in different research domains.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.