Introduction Growth retardation is a common problem in children with CKD. This study aims to describe growth, prevalence of short stature before RTx, catch‐up growth after RTx, and associated factors. Methods We retrospectively reviewed 74 renal allograft recipients who underwent RTx at Fundación Cardioinfantil, Colombia, between January 2008 and September 2016 with follow‐up for 2 years afterwards. Pre‐RTx Height_SDS and demographic characteristics were compared between children with normal and short stature. Post‐RTx Height_SDS at 1 and 2 years post‐RTx and FAH, when available, were retrieved. Children were classified into catch‐up growth and no catch‐up growth groups depending on whether or not Height_SDS increased ≥0.5 per year within the first 2 years post‐RTx. Possible associated factors were compared. Results Seventy‐four patients were included. Mean age at RTx was 11 ± 4.0 years, and 43.2% (32/74) were females. Mean Height_SDS for the entire study population at pre‐RTx was −2.8 ± 1.5. Before RTx, 68.9% (51/74) had short stature, and 44.6% (33/74) had severe short stature. 37.2% presented catch‐up growth post‐RTx. Time on dialysis was associated with short pre‐RTx stature (OR 1.66; 95% CI [1.15‐2.39]; P = .006) and catch‐up growth (OR 2.15; 95% CI [1.15‐3.99]; P = .016). 44.59% (33/74) reached FAH, and 48.4% (16/33) presented short FAH. Conclusions Growth continues to be suboptimal after RTx. Given that pre‐RTx height is a significantly associated factor, it is important to plan early interventions in terms of growth improvement in these children.
Introduction Renal biopsy is the principal instrument to evaluate the diagnosis and prognosis of children with kidney disease. There are relatively few studies establishing epidemiology of its findings in the pediatric population. Methods A descriptive study was conducted to describe characteristics of pediatric patients who had undergone a renal biopsy over the last 10 years in a national reference center, trying to accomplish an etiopathogenic approach of biopsy findings. Results 241 patients were included. Most frequent indications were nephrotic syndrome (34.1%) and systemic disease with renal involvement (30.2%). The most prevalent biopsy diagnosis was glomerulonephritis (44%) and among these patients, glomerulonephritis mediated by immune complexes was the most frequent pathogenic type (90.5%). When the biopsy was indicated for proteinuria plus hematuria and systemic disease with renal involvement, the most frequent biopsy diagnosis was glomerulonephritis (60 and 85%, respectively). For isolated hematuria, the predominant biopsy diagnosis was inherited diseases of the glomerular basement membrane (70%) and for nephrotic syndrome, podocytopathy (82%). Glomerulonephritis was more frequent in patients older than 10 yrs (65%) and the rate of postbiopsy major complications was low (1.2%). ConclusionImmune complex glomerulonephritis was the most frequent histological finding, differing from previous reports. To our knowledge this is the first description that classifies biopsy findings according to the probable pathogenic mechanism.
Recomendaciones para el uso de la hormona de crecimiento humana recombinante en pacientes pediátricos de talla baja en ColombiaRecommendations for treatment with recombinant human growth hormone in pediatric patients in Colombia
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.