Summary Hepatitis A is a vaccine-preventable, communicable disease of the liver caused by the hepatitis A virus (HAV). The infection is transmitted via the fecal-oral route, usually from direct person-to-person contact or consumption of contaminated food or water. Hepatitis A is an acute, self-limited disease that does not result in chronic infection. HAV antibodies (immunoglobulin G [IgG] anti-HAV) produced in response to HAV infection persist for life and protect against reinfection; IgG anti-HAV produced after vaccination confer long-term immunity. This report supplants and summarizes previously published recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding the prevention of HAV infection in the United States. ACIP recommends routine vaccination of children aged 12–23 months and catch-up vaccination for children and adolescents aged 2–18 years who have not previously received hepatitis A (HepA) vaccine at any age. ACIP recommends HepA vaccination for adults at risk for HAV infection or severe disease from HAV infection and for adults requesting protection against HAV without acknowledgment of a risk factor. These recommendations also provide guidance for vaccination before travel, for postexposure prophylaxis, in settings providing services to adults, and during outbreaks

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Introduction The coronavirus disease 2019 (COVID-19) pandemic has disrupted healthcare services, reducing opportunities to conduct routine hepatitis C virus (HCV) antibody screening, clinical care, and treatment. Therefore, people living with undiagnosed HCV during the pandemic may later become identified at more advanced stages of the disease, leading to higher rates of morbidity and mortality rates. Further, unidentified HCV-infected individuals may continue to unknowingly transmit the virus to others. Methods To assess the impact of the COVID-19 pandemic, data were evaluated from a large national reference clinical laboratory and national estimates of dispensed prescriptions for HCV treatment. Investigators estimated the average number of HCV antibody tests, HCV antibody positive test results, and HCV RNA positive test results by month, January–July for 2018/2019, compared with the same months in 2020. To assess the impact of HCV treatment, dispensed HCV direct acting antiretroviral medications were examined for the same time periods. Statistical analyses of trends were performed using negative binomial models. Results Compared with the 2018/2019 months, HCV antibody testing volume decreased 59% during April 2020 and rebounded to a 6% reduction in July. The number of HCV RNA positive results fell by 62% in March 2020 and remained 39% below the baseline by July 2020. For HCV treatment, prescriptions decreased 43% in May, 37% in June, and 38% July relative to corresponding months in 2018/2019. Conclusions During the COVID-19 pandemic, continued public health messaging, interventions and outreach programs to restore HCV testing and treatment to pre-pandemic levels, and maintenance of public health efforts to eliminate hepatitis C infections remain important.