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HgCl 2 induced fragmentation of rough endoplasmic reticulum. Ballooning of Golgi apparatus. Nuclear and cytoplasmic degeneration of pyramidal neurons of rat cerebral cortex. HgCl 2 increased reactive oxygen species. Melatonin, free radical scavenger improved neuronal damage caused by HgCl 2 .

Peeling skin syndrome is a relatively rare clinical case with pathology of apparently normal skin that needs clinical details to reach accurate diagnoses. Hence, this case was used as examples to declare how it is important for both the pathologist and the dermatologist to cooperate to reach an accurate diagnosis.

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