The purpose of this study was to investigate whether mediation of Islamization of Human Knowledge (IOHK) existed between the relationships of, Islamic Spiritual Intelligence (ISI), and leadership Competencies of Student Leaders (LCSL). Three hundred and seventy-two (N=372) students of IIUM were stratified and randomly selected from the population of student leaders. A full-fledged structural equation modeling was employed to validate the proposed model. The findings revealed that there was a significant positive effect of Islamic Spiritual Intelligence (ISI) on the Leadership Competencies of Student Leaders (LCSL) through the Islamization of Human Knowledge (IOHK) as a mediator. Besides, IOHK completely mediates through ISI and LCSL. This study could be useful in developing young minds to become ethical leaders and enhance the Islamization process at the International Islamic University Malaysia (IIUM).
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