New N-substituted ?-aminonitrile derivatives from menthol were synthesized by
consecutive succinic ester formation, propargylation, 1,3-dipolar Huisgen
cycloaddition and Strecker reaction. The structures of the synthesized
compounds were confirmed by diverse spectroscopic techniques including
1HNMR, 13C-NMR, ESI-MS, and IR. The novel synthesized compounds were
evaluated for their in vitro antibacterial activities against Staphylococcus
aureus as Gram-positive and Escherichia coli as Gram-negative bacteria.
These compounds demonstrated a strong inhibitory effect against S. aureus
with the minimum inhibitory concentration (MIC) values ranged from 32-128 ?g
mL-1. Derivatives 6a2, 6b1, 6b4, and 6b5 with a MIC value of 32 ?g mL-1
exhibited the best inhibitory effects.
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