A number of mechanisms (both mechanical and chemical) have been proposed as the cause of dentin adhesion. Extensive research in Japan during the past 10 years has shown that strong, long‐lived bonds between resin and living dentin will form when a monomer such as 4‐META, which contains both hydrophilic and hydrophobic chemical groups, penetrates the tissue and polymerizes in situ. This resin‐impregnation creates a transitional “hybrid” layer, that is neither resin nor tooth, but a hybrid of the two. The thin layer of resin‐reinforced dentin locks the two dissimilar substances together on a molecular level, sealing the surface against leakage and imparting a high degree of acid resistance.
Summary. This review demonstrates the following points : 1. By glucose tolerance test and the determination of non-fasting blood sugar values, mice of KK strain (a Japanese strain) have been shown to be in a diabetic state. 2. KK mice have greater than normal body weights, and moderate obesity. 3. Pancreatic insulin activity and adenohypophyseal growth hormone content of KK mice are greater than those of C75BL mice. 4. The pancreas of KK mice presents many striking changes, such as the hypertrophy and hyperplasia of the islets, the hypertrophy and degranulation of B cells, the abundance of B cell ribosomes and endoplasmic reticulum, the enlargement of the Golgi areas of B cells, and the diminution of the zinc content of insular cells. 5. In other organs (eg. adenohypophysis, liver, adrenal and parathyroid) of KK mice, many changes are also observed. The above features of KK mice are discussed in relation to the presumed metabolic disorder in the mice.
Etudes d' une souche diabgtique (KK) de souris.Rgsum~. 1. Un 6tat diab6tique est ddmontr6 chez des souris d'une souehe japonaise, la souche KK, mis en gvideuce par une 616vation du sucre sanguin et par une diminution de la toldrance au glucose. 2. Le poids corporel des souris KK d@asse la normale; il s'agit d'une obdsit6 mod6r6e. 3. L'activit6 insu]inique du pancrdas et le contenu en hormone de croissance de l'hypophyse de souris KK dgpassent ceux observgs chez des souris C57BL. 4. t-Iistologiquement, on trouve chez les souris KK une hypertrophic et une hyperplasie des riots de Langerhans, une hypertrophic et une ddgranulation des eellules B, une abondance de ribosomes et de r6ticulum endoplasmique des cellules B, un ddveloppement marqu6 de la r@gion de Golgi des m6mes eellules, et une diminution du contenu en zinc des cellules insulaires. D'autres anomalies ont 6galement dr6 observges dans d'autres organes des souris KK, plus partieuli~rement pour l'hypophyse, le foie, les surr6nales et la parathyroide.
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