the subgroups of patients with JIA. The mean (SD) antibody levels in the children with JIA were significantly lower (175.5 (118.4) mIU/ ml) than those of the healthy subjects (317.08 (180.5) mIU/ml) There was no diVerence between the sexes in vaccine responsiveness. When the antibody levels between the two vaccination schedules were compared in healthy children, there was no statistical diVerence. However, there was a slightly higher, but statistically insignificant, response in JIA subjects vaccinated in group II than in those in group I. The vaccine responsiveness was not influenced either by methotrexate or prednisolone treatment. However, there was a negative correlation between prednisolone dose and anti-HBs titre (r=−0.23). Conclusion-Children with JIA responded adequately to hepatitis B vaccination, and this response was not negatively influenced by immunosuppressive treatment. The more appropriate vaccination schedule for children with JIA is the schedule given at 0, 1, and 6 months.
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