Molluscum contagiosum (MC) is most frequently a self-limiting benign viral skin disease. Transmitted by direct skin contact, it is characterized by flesh-colored, dome-shaped, umbilicated lesions. Diagnosis of MC is often done clinically, but when needed, biopsy can be performed, in which characteristic Henderson-Patterson bodies, representing intracytoplasmic assemblies of the virus, are pathognomonic. Atypical presentations of MC are rare in immunocompetent individuals and are challenging to diagnose. We report a case of giant MC, presenting as an ulcero-proliferative growth, in neck of an 8-month-old female child. Fine-needle aspiration cytology smears revealed characteristic intracytoplasmic molluscum bodies. The diagnosis was subsequently confirmed by histopathology. In this case, cytological examination helped in reaching the correct diagnosis, in a clinically unsuspected case.
Ni-aluminides are an important class of intermetallics from technological point of view. Ni-Al phase diagram has been studied in detail experimentally as well as theoretically. It is known that if annealed at low temperature, the first alloy phase is usually NiAl3 according to Bené's rule. It is also understood that heat of formation may get modified by local densities of the constituents forming the alloy. In this regard, it is important to identify a kinetic length scale for defining “local density” in a system. We have deposited ultrathin multilayers of Ni and Al of layer thickness in tens of nanometres with Ni:Al stoichiometric ratio as 3:1 and 1:3, respectively. Considering these stoichiometry, Ni3Al and NiAl3 are the thermodynamically favoured alloy phases in these samples. We used x-ray reflectivity, polarized neutron reflectivity, x-ray diffraction, and secondary ion mass spectroscopy to follow the alloy formation after annealing and identified the alloy phases at interfaces with nanometre resolution. Diffusion length of Ni and Al was obtained using Darken's law. Our results predict that ‘diffusion length’ is the unique length scale that connects kinetics to local density. In another interesting observation, using “virtual Kirkendall markers” at the interfaces, we showed asymmetry in consumption of Al for alloy formation, at Al on Ni (Al/Ni) and Ni on Al (Ni/Al) interfaces by comparing as-deposited and annealed states with respect to the markers.
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