No abstract

Influenza vaccination elicits significant neutralizing antibody and T-cell responses to pandemic H1N1 2009 influenza virus. However, in response to vaccination, increases in neutralizing antibody titers were comparatively lower but T-cell responses were higher in older participants. Therefore, our study suggests that memory T-cells may play a crucial role in protecting older individuals against pandemic H1N1 2009 infection.

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As the biggest greenhouse gases (GHGs) emitter, China’s climate mitigation has tremendous contributions to the global carbon and air pollutants reductions. This study is trying to extract the co-benefit on air quality, public health and economic costs in China and worldwide from China’s GHGs mitigation policy. We construct two scenarios, with moderate climate mitigation action worldwide, versus more stringent climate mitigation action in China. We use the GAINS model to predict the GHGs and air pollutants emissions in the two scenarios, and a state-of-the-art global chemical transport model to simulate the annual PM2.5 concentrations. We then use IMED|HEL, which is a health assessment model, to estimate the health impacts and economic cost of PM2.5 pollution in each country. Results show China’s mitigation has significant impact on both air quality and health improvement in eastern China and eastern Asia, a little bit impact in the rest of Asia. The improved air quality could avoid 0.37 million premature deaths due to ambient PM2.5 exposure by 2050s globally, with the majority happening in China. We use the willingness to pay method to estimate the economic benefits from the improved air quailty, and find that the reduced ambient PM2.5 concentration could avoid $406 billion and $1206 billion economic costs by 2030s and 2050s globally, with China the largest fraction of 98.5% ($400 billion) and 99.5% ($1200 billion), respectively. The reduced ambient PM2.5 exposure can also avoid 11.3 million cases morbidity globally by 2050s, due to asthma attacks and hospital admissions. Our study shows most of the economic benefits from air quality improvement due to China’s mitigation happens in China, followed by the eastern Asia (such as South Korea and Japan) and the rest of Asia. Health improvement is the main fraction of the potential benefits, such as saving health expenditure, increasing the work time.

Adopting the constructs of exposure, reactivity, and recovery, from stress and coping frameworks, this study investigated three models of discrimination, adjustment, and ethnic/racial identity among 76 African American, 145 Asian American, and 129 Latinx adolescents who were majority United Statesborn. The sample includes adolescents sampled from public schools in a large urban area in the northeastern United States, 62% female and with an average age of 14.3 years. Multilevel analyses support an exposure effect (Model 1) where a higher level of ethnic/racial identity (ERI) commitment was associated with a 28% reduction in experiencing discrimination stress. The negative effects of discrimination were attenuated by ERI commitment and centrality/private regard, while effects were exacerbated by ERI exploration (Model 2). Two approaches investigated next-day and longer-term recovery from discrimination (Model 3). With the exception of positive mood and anxiety, the data support recovery from discrimination stress. Discrimination is discussed in the development and maintenance of health disparities.