Covalent organic frameworks (COFs) are penetrated with uniform and ordered nanopores, implying their great potential in molecular/ion separations. As an imine-linked, stable COF, TpPa-1 is receiving tremendous interest for molecular sieving membranes. Theoretically, atomically thin TpPa-1 monolayers exhibit extremely high water permeance but unfortunately no rejection to ions because of its large pore size (∼1.58 nm). The COF monolayers tend to stack to form laminated multilayers, but how this stacking influences water transport and ion rejections remains unknown. Herein, we investigate the transport behavior of water and salt ions through multilayered TpPa-1 COFs by nonequilibrium molecular dynamics simulations. By analyzing both the interfacial and interior resistance for water transport, we reveal that with rising stacking number of COF multilayers exhibit increasing ion rejections at the expense of water permeance. More importantly, stacking in the offset eclipsed fashion significantly reduces the equivalent pore size of COF multilayers to 0.89 nm, and ion rejection is correspondingly increased. Remarkably, 25 COF monolayers stacked in this fashion give 100% MgCl2 rejection, whereas water permeance remains 1 to 2 orders of magnitude higher than that of commercial nanofiltration membranes. This work demonstrates the rational design of fast membranes for desalination by tailoring stacking number and fashion of the COF monolayers.

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A fluorescent probe (N-(4-methyl-2-oxo-2H-chromen-7-yl)-2,4-dinitrobenzenesulfonamide), which exhibits high selectivity to glutathione and cysteine among amino acids including sulphur-containing methionine and metal ions, was synthesized. The experiments demonstrate that the fluorescent probe is a reliable and specific probe for glutathione and cysteine in living cells.

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