Career satisfaction remains high among young vascular surgeons. In this cohort of vascular surgery graduates, we found that women were more likely to pursue academic positions than men, with mentorship, ability to teach, and complexity of cases commonly cited as reasons for this career choice. However, whether young women stay in academia and what factors affect academic retention will need further evaluation.
Thin-sectioning of Bacillus subtilis ATCC 6633 protoplasts and cells has revealed electron-dense particles resembling cytoplasmic ribosomes in mesosomal tubules and vesicles.
MATHESON, A., M. C. M. KWONG, and R. CHEUNG. 1972. Influences of environmental ionic strength, pH, and magnesium ion on bactericidal and lytic activities of 0-lysin on Bacillris subtilis. Can. J. Microbiol. 18: 1665-1670. The technique of lyophilization has been used to prepare 0-lysin that can be stored in aliquots at ordinary refrigeration temperatures. It has permitted the determinations of environmental ionic strength, pH, and magnesium ion concentration favoring bactericidal and lytic activities of this agent. Killing of cells as well as lysis of protoplasts of Bacillus subtilis were favored in environments not more than 0.2 nor less than 0.15 in ionic strength. Of the environmental pH tested (6.0, 7.0, and 7 . 9 , lysis of cells and of protoplasts was most efficient at pH 7.5, whereas bactericidal action was relatively unaffected in this range. The effectiveness of bactericidal action and of lysis of protoplasts decreased as the amount of Mgz+ in the environment increased. MATHESON, A., M. C. M. KWONG et R. CHEUNG. 1972. Influences of environmental ionic strength, pH, and magnesium ion on bactericidal and lytic activities of 0-lysin on Bacillus subtilis. Can. J. Microbiol. 18: 1665-1670.La lyophilisation a Ct C utilisee pour preparer de la 0-lysine qui peut Ctre gardie aux temperatures normales de refrigeration. Ceci nous a permis de determiner les effets de la concentration ionique, du pH et de la concentration en ion magnesium sur les activitts bactericides et lytiques de la p-lysine. La destruction ainsi que la lyse des protoplastes de Bacillrrs srrbtilis sont favoriskes dans des milieux de concentration ionique variant entre 0.2 et 0.15. Parmi les valeurs de pH BtudiCes (6.0, 7.0 et 7.5) pH 7.5 s'est aver6 le plus efficace pour obtenir la lyse des cellules, tandis que I'action bactkricide n'est relativement peu affectee par ces pH. L'action bactericide et la lyse des protoplastes decroissent lorsqu'on augmente la quantite de Mgz+ dans le milieu.[Traduit par le journal]
Background: Advanced peripheral arterial disease is associated with an overall annual mortality between 20-40%. Amputees are at particularly high r isk for per ioperative and long-term mortality and may benefit from palliative care programs to improve quality of life and to align medical treatments with their goals of care. As studies of palliative care in vascular patients are scarce, we sought to examine palliative care utilization using below knee amputation (BKA) as a surrogate for advanced peripheral arterial disease. Methods: All patients who underwent below knee amputation over a 5-year period at a single large academic medical center were identified through chart review. Demographics, preoperative conditions, intraoperative factors, and perioperative outcomes were recorded. The primary outcome was palliative care consultation at the time of the amputation. The secondary outcomes included one-year mortality and palliative care consultation prior to death. Results: The cohort comprised 111 patients (76 men, 35 women) who received BKA for chronic limb threatening ischemia. Three patients (2.7%) received palliative care consultations at the time of their amputation. Of these, one had been obtained remotely for an oncologic condition and the others for surgical decision-making. Follow-up was available for 73 patients. One-year mortality was 21.9% ( n = 16) at a mean of 102 ± 86 days after BKA. Among patients who died within 1 year of their amputation, 37.5% ( n = 6) received palliative care consultations prior to their death. The median interval between amputation and palliative consultation was 26 (IQR 14-81) days. The median interval between palliative consultation and death was 9 (IQR 4-39) days. Conclusion: Palliative care services were rarely provided to patients with advanced peripheral arterial disease. When obtained, consultations occurred closer to death than to amputation suggesting a missed opportunity to receive the benefits of early evaluation. Future studies can be aimed at identifying a cohort of vascular patients who would most benefit from early palliative evaluation and determining if palliative consultations alter health care utilization patterns and outcomes for vascular patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.