The objective of this study was to identify sorghum varieties that have growth and grain yield potential under saline conditions. The study was conducted in 2016 at a greenhouse of the Embrapa Semiárido, in Petrolina, state of Pernambuco, Brazil (9° 8’ 8.9’’ S, 40° 18’ 33.6’’ W, and altitude of 373 m). A randomized block experimental design, with a 6 × 5 factorial arrangement, and three replications was used. The treatments consisted of six grain sorghum varieties (1011-IPA, 2502-IPA, 2564-IPA, 2600-IPA, Ponta Negra, and Qualimax), and five salinity levels of the irrigation water (ECw = 0, 1.5, 3.0, 6.0, and 12.0 dS m-1). Plant height, stem diameter, dry matter yield, width and length of the +3 leaf, total leaf area, water use efficiency, and grain yield were evaluated. The sorghum varieties 2502-IPA and 1011-IPA presented the highest grain yields when using an ECw of 6.0 dS m-1, followed by Ponta Negra, Qualimax, and 2600-IPA. The 2564-IPA, 2600-IPA, and Qualimax varieties were more sensitive to the salinity effects, with reductions of 50% of the production with ECw of 3.52, 2.75, and 4.38 dS m-1, respectively.