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Although a theory of the climatology of tropical cyclone formation remains elusive, high-resolution climate models can now simulate many aspects of tropical cyclone climate. T he effect of climate change on tropical cyclones has been a controversial scientific issue for a number of years. Advances in our theoretical understanding of the relationship between climate and tropical cyclones have been made, enabling us to understand better the links between the mean climate and the potential intensity (PI; the theoretical maximum intensity of a tropical cyclone for a given climate condition) of tropical cyclones. Improvements in the capabilities of climate models, the main tool used to predict future climate, have enabled them to achieve a considerably improved and more credible simulation of the present-day climatology of tropical cyclones. Finally, the increasing ability of such models to predict the interannual variability of tropical cyclone formation in various regions of the globe indicates that they are capturing some of the essential physical relationships governing the links between climate and tropical cyclones. HURRICANES AND CLIMATEPrevious climate model simulations, however, have suggested some ambiguity in projections of future numbers of tropical cyclones in a warmer world. While many models have projected fewer tropical cyclones globally (Sugi et al. 2002;Bengtsson et al. 2007b; Gualdi et al. 2008; Knutson et al. 2010), other climate models and related downscaling methods have suggested some increase in future numbers (e.g., Broccoli and Manabe 1990;Haarsma et al. 1993; Emanuel 2013a). When future projections for individual basins are made, the issue becomes more serious: for example, for the Atlantic basin there appears to be little consensus on the future number of tropical cyclones or on the relative importance of forcing factors such as aerosols or increases in carbon dioxide (CO 2 ) concentration. One reason could be statistical: annual numbers of tropical cyclones in the Atlantic are relatively small, making the identification of such storms sensitive to the detection method used.Further, there is substantial spread in projected responses of regional tropical cyclone (TC) frequency and intensity over the twenty-first century from downscaling studies (Knutson et al. 2007; Emanuel 2013a). Interpreting the sources of those differences is complicated by different projections of large-scale climate and by differences in the present-day reference period and sea surface temperature (SST) datasets used. A natural question is whether the diversity in responses to projected twenty-firstcentury climate of each of the studies is primarily | a reflection of uncertainty arising from different large-scale forcing (as has been suggested by, e.g., Villarini et al. 2011;Villarini and Vecchi 2012;Knutson et al. 2013) or whether this spread reflects principally different inherent sensitivities across the various downscaling techniques, even including different sensitivity of responses within the same model due to...

Peroxisomes play a central role in lipid metabolism, and their function depends on molecular oxygen. Low oxygen tension or von Hippel-Lindau (Vhl) tumor suppressor loss is known to stabilize hypoxia-inducible factors alpha (Hif-1α and Hif-2α) to mediate adaptive responses, but it remains unknown if peroxisome homeostasis and metabolism are interconnected with Hif-α signaling. By studying liver-specific Vhl, Vhl/Hif1α, and Vhl/Hif2α knockout mice, we demonstrate a regulatory function of Hif-2α signaling on peroxisomes. Hif-2α activation augments peroxisome turnover by selective autophagy (pexophagy) and thereby changes lipid composition reminiscent of peroxisomal disorders. The autophagy receptor Nbr1 localizes to peroxisomes and is likewise degraded by Hif-2α-mediated pexophagy. Furthermore, we demonstrate that peroxisome abundance is reduced in VHL-deficient human clear cell renal cell carcinomas with high HIF-2α levels. These results establish Hif-2α as a negative regulator of peroxisome abundance and metabolism and suggest a mechanism by which cells attune peroxisomal function with oxygen availability.

Future tropical cyclone activity is a topic of great scientific and societal interest. In the absence of a climate theory of tropical cyclogenesis, general circulation models are the primary tool available for investigating the issue. However, the identification of tropical cyclones in model data at moderate resolution is complex, and numerous schemes have been developed for their detection.The influence of different tracking schemes on detected tropical cyclone activity and responses in the Hurricane Working Group experiments is examined herein. These are idealized atmospheric general circulation model experiments aimed at determining and distinguishing the effects of increased sea surface temperature and other increased CO 2 effects on tropical cyclone activity. Two tracking schemes are applied to these data and the tracks provided by each modeling group are analyzed.The results herein indicate moderate agreement between the different tracking methods, with some models and experiments showing better agreement across schemes than others. When comparing responses between experiments, it is found that much of the disagreement between schemes is due to differences in duration, wind speed, and formation-latitude thresholds. After homogenization in these thresholds, agreement between different tracking methods is improved. However, much disagreement remains, accountable for by more fundamental differences between the tracking schemes. The results indicate that sensitivity testing and selection of objective thresholds are the key factors in obtaining meaningful, reproducible results when tracking tropical cyclones in climate model data at these resolutions, but that more fundamental differences between tracking methods can also have a significant impact on the responses in activity detected.

Much of the work done in the field of tangible interaction has focused on creating tools for learning; however, in many cases, little evidence has been provided that tangible interfaces offer educational benefits compared to more conventional interaction techniques. In this paper, we present a study comparing the use of a tangible and a graphical interface as part of an interactive computer programming and robotics exhibit that we designed for the Boston Museum of Science. In this study, we have collected observations of 260 museum visitors and conducted interviews with 13 family groups. Our results show that visitors found the tangible and the graphical systems equally easy to understand. However, with the tangible interface, visitors were significantly more likely to try the exhibit and significantly more likely to actively participate in groups. In turn, we show that regardless of the condition, involving multiple active participants leads to significantly longer interaction times. Finally, we examine the role of children and adults in each condition and present evidence that children are more actively involved in the tangible condition, an effect that seems to be especially strong for girls.