Background: Hypertension affects over 26.3% of the Egyptian population and is considered one of the most significant risk factors for morbidity and mortality from coronary heart disease, chronic renal failure, and stroke. Lifestyle modification especially physical exercise is a mainstay in the management of blood pressure control. Objective: We sought to assess the effect of graded walking exercise on blood pressure in hypertensive patients Methods: Our study comprised 40 hypertensive patients with mild to moderate hypertension divided into 2 equal groups. Group I (experimental group) patients were given pharmacological medications and encouraged to graded walking exercise program and followed-up by the researchers over a period of eight weeks. Group II (control group) patients were given standard pharmacological medications only. Results: The results showed insignificant difference between GI and GII in their weight and BMI on 2 nd , 6 th , and 8 th weeks comparing with 1 st week. A non-significant improvement between GI and GII was found in heart rate as a short term effects through walking exercises. (t = 2.03, p= 0.05). Comparing between group I and group II regarding the benefits of walking program exercises on heart rate, systolic, and, diastolic blood pressure; a statistical significant difference was observed on 4 th , 6 th , and 8 th weeks in relation to heart rate (p value = 0.0001, 0.005, and 0.0001), respectively, systolic blood pressure (p value = 0.0001, 0.006, and 0.0001), respectively, and diastolic blood pressure (p value = 0.009, 0.024, and 0.002) respectively. Conclusion: The results of the study strongly support the beneficial effect of aerobic regular exercise in reduction of systolic & diastolic blood pressure and heart rate in hypertensive patients with pharmacologic treatment. Special attention should be paid to aerobic exercise for hypertensive patients and should be integral component of hypertension education program.
Fanconi anaemia (FA) is a rare genetic abnormality. Most of FA reported from the sub-Saharan population came from southern Africa, with many patients linked to a mutation in the FANC G gene. Classic triads of this disorder are: a varied malformation, bone marrow failure, and short stature. This disorder is also associated with predisposition to malignancies. These multiple manifestations, sometimes not uniform, often cause diagnostic delay. We here report a 13-year-old Senegalese boy with FA. He was followed up for polydactyly-repair surgery. Importantly, pre-operative blood checkup revealed severe anaemia, which prompted us to perform bone marrow aspiration: examination revealed dysmyelopoiesis. Being triggered by this, systematic examinations were performed, which revealed other signs indicative of FA; i.e., radial spine abnormalities, triangular face, etc. The diagnosis of FA was strongly suggested, which prompted genetic examination. The chromosomal breakage test detected cellular hypersensitivity to DNA, which confirmed the diagnosis. He is receiving transfusion support, and androgens use is being considered. This case highlights the importance of preoperative examination. Physicians must be aware that FA, although its incidence is low, can be hidden behind infantile anaemia.
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