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Wheat (Triticum aestivum) is an important grains plant that can sustain food security and holds high nutritional values to the benefit of mankind. Activities of salinity in arid and semi-arid region have drastically reduced the production of wheat grains. Selenium (Se) is a micronutrient required by plants in small concentration to aid their growth. This study was aimed at identifying impact of Se on salinity-stressed wheat plants. Wheat seeds were soaked for eight hours in 0, 50, 100 and 150 mg/L Selenite concentrations and five sterilize-treated seeds were sown in 5 kg quantity of soil. This was subjected to 0, 100 and 200 mM of Sodium chloride (NaCl) concentration, respectively. The study revealed that Se increased production/expression of superoxide dismutase and catalase enzymes under salinity stress, thus growth of wheat plants was improved. Although the effects of Se on the wheat plants were concentration-based, nevertheless low lipid peroxidation and plant growth at 150 mg/L of Se were observed. Toxicity of Se to wheat plant could occur when there is no salinity stress. Therefore, farmers are encouraged to prime wheat seeds with 150 mg/L Se when cultivating saline soils.