No abstract

The ZnO nanoparticle synthesis using the leaf part of Chamaecostus cuspidatus was characterized using UV–Vis spectrophotometry, IR, XRD, DLS, FESEM, EDX, TEM, AFM and XPS. The MTT assay was used to examine the cytotoxicity activity against lung epithelial and breast cell lines, and the IC50 value was determined. The presence of ZnO nanoparticles, which range in size from 200 to 800 nm, was confirmed by the absorption peak at 350 nm. The median particle size was 145.1 nm, and the ζ -the potential was -19.45 mV, showing that ZnONP is stable. Zinc, carbon, and oxygen contribute to the elemental composition of ZnONP, as determined by EDX analysis. MTT assay was used to investigate in vitro cytotoxicity in MCF-7 and A549 cell lines. The cytotoxicity activity IC50 value was determined to be 30 μg/mL for the A549 cell line and 37 μg/mL for the MCF-7 cell line.

No abstract

Head and neck cancer, one of the most commonly prevalent malignancies globally is a complex category of tumours that comprises cancers of the oral cavity, pharynx, and larynx. A specific subgroup of such cancers has been found with some unique chromosomal, therapeutic, and epidemiologic traits with the possibility of affecting via co‐infection. About 25% of all head and neck cancers in the population are human papillomavirus infection (HPV)‐associated, typically developing in the oropharynx, which comprises the tonsils. In the period of efficient combined antiviral treatment, HPV‐positive oral cancers are also becoming a significant contributor to illness and fatality for Human Immunodeficiency Virus (HIV)‐infected persons. Although the prevalence and historical background of oral HPV transmission are not thoroughly understood, it seems likely that oral HPV transmission is relatively frequent in HIV‐infected people when compared to the overall population. Therefore, there is a need to understand the mechanisms leading to this co‐infection, as there is very little research related to that. Hence, this study mainly focus on the therapeutical and biomedical analysis of HPV and HIV co‐infection in the above‐mentioned cancer, including oral squamous cell carcinoma.