Abstrak Sindrom Ovarium Polikistik (SOPK) merupakan kelainan endokrin dan metabolik pada wanita usia reproduksi. SOPK merupakan kumpulan gejala dari amenore, oligomenore, infertilitas, obesitas, hirsutisme, acne, alopesia, dan akantosis nigrikan. Resistensi insulin diyakini sebagai salah satu penyebab tersering dari SOPK melalui berbagai mekanisme. Tujuan penelitian ini adalah untuk mengetahui hubungan resistensi insulindengan gambaran klinis SOPK. Penelitian ini dilakukan pada pasien SOPK dengan menggunakan studi cross sectional dengan pendekatan retrospektif, yaitu mengumpulkan kejadian masa lalu dari tahun 2009 - 2011, jumlah sampel 105 orang. Analisis statistik yang digunakan adalah uji chi-square. Hasil penelitian didapatkan 33,3% penderita SOPK mengalami resistensi insulin. Berdasarkan gambaran klinis 35,23% amenore, 64,77% oligomenore, 72,04% infertilitas, 50,5% obesitas, 0,95% hirsutisme, acne 20%, alopesia dan akantosis nigrikan0%. Dari 33,3% SOPK dengan resistensi insulin 40% amenore, 60% oligomenore, 71,9% infertilitas, 77,14% obesitas, dan 0% hirsutisme. Berdasarkan hasil uji statistik ditemukan hubungan bermakna antara resistensi insulin dengan obesitas (p<0,05) dan tidak ditemukan hubungan bermakna antara resistensi insulin dengan infertilitas, hirsutisme, dan acne (p>0,05).Kata Kunci: SOPK, resistensi insulin, gambaran klinisAbstract Polycystic Ovary Syndrome (PCOS) is an endocrine and metabolic disorders that is common in reproductive-aged women. PCOS is a group of symptoms, such as amenorrhea, oligomenorrhea, infertility, obesity, hirsutism, acne, alopecia, and achanthosis nigricans. Insulin resistance is believed to be one of the most common causes of PCOS through a various mechanisms. The objective of this study was to find out the relationship between insulin resistance and clinical manifestation of PCOS. This research was done in patients with PCOS using cross sectional study with retrospective approach. Data was collected from 2009-2011, with the sample of 105 patients. This research used statistical analysis, that was chi square test. This research found that 33.3% patients of PCOS have insulin resistance. Based on clinical manifestation found that 35.23% amenorrhea, 64.77% oligomenorrhea, 72.04% infertility, 50.5% obesity, 0.95% hirsutism, 20% acne, 0% alopecia and achanthosis nigricans. From 33.3% PCOS with insulin resistance, 40% amenorrhea, 60% oligomenorrhea, 71.9% infertility, 77.14% obesity, and 0% hirsutism. The results showed that there is a significant relationship between insulin resistance and obesity (p<0.05) and no significant reslationship between insulin resistance and infertility, hirsutism, and acne (p>0.05).Keyword: PCOS, insulin resistance, clinical manifestation
BACKGROUND: Pain is defined as an unpleasant sensory and emotional experience associated with actural or potential tissue damage. Cognitive impairment can occur due to various processes in the brain, one of which resulted from chronic pain. Brain-derived neurotrophic factor (BDNF) is a neurotropin that plays a role in mediating disinhibition in the excitability of the motor cortex of the brain and inhibitory function in descending pain pathways. Chronic pain of periodontitis causes systemic inflammation that activates microglia resulting in degeneration of CA1 pyramidal neurons in the hippocampus and affects cognitive function, especially spatial memory. AIM: The objectives of this study were to determine the correlation between BDNF levels, spatial memory, and histopathology of hippocampus on periodontitis Wistar rats. METHODS: This observational prospective study was conducted between January and April 2022 at Laboratory Negeri Semarang University. Frontal inferior teeth ligation of Wistar rats was carried out to induce periodontitis for 4 weeks. Chronic pain was assessed using Rat Grimace Scale. Morris water maze (MWM) adaptation was applied for 4 weeks and then BDNF levels, spatial memory, and histopathology of hippocampus were investigated. T-test independent and spearman correlation test were used to data analysis. RESULTS: Among 12 rats, the mean of BDNF levels, spatial memory, and histopathology of hippocampus score were 7.57 ng/mL, 65.08 second, and 3, respectively. There were significant relationships between BDNF levels (p = 0.028), spatial memory (p = 0.001), and histopathology of hippocampus score (p = 0.017) on Wistar rats with chronic pain. Strong correlation (r = −0.721, r2 = 0.52, p = 0.004) between BDNF levels and spatial memory, and moderate correlation (r = −0.597, p = 0.02) between BDNF levels and histopathology of hippocampus score was obtained. There was no significant correlation between spatial memory and histopathology of hippocampus score. CONCLUSIONS: There were significant differences between BDNF levels, spatial memory, and histopathology of hippocampus on periodontitis Wistar rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.