Background. Mycobacterium tuberculosis has become the leading cause of morbidity and death in humans worldwide. Thus, genetic variability of the host plays a major role in human susceptibility to the pathogen, among others. Therefore, the objective of this finding was to assess the association of genetic polymorphisms of cytokines with tuberculosis infection. Method. A cross-sectional study was conducted between January and May 2018. Five ml of whole blood was collected and extracted the genomic DNA through simple salting out method. The patterns of genetic polymorphism were determined by amplification refractory method PCR using specific primers. Finally, the PCR run on electrophoresis of agarose gel and the band was visualized under UV light. A logistical regression model has been adapted to assess the association of genetic polymorphisms with tubercular infection. In order to determine the association between the explanatory and outcome variable, the odds ratio with 95% CI was calculated. P < 0.05 is a statistically significant value. Result. In present study, the frequency of TNF-α -308 G allele and GG genotype OR (95% CI)= 0.20 (0.11-0.37), and OR (95% CI)= 0.29 (0.18-0.46)), respectively) and IFN-γ +874 A allele and AA genotype OR (95% CI)= 3.80 (2.11-6.86) and (OR (95% CI)= 1.61(1.13-2.28), respectively) were significantly associated with tuberculosis incidence. In contrast, there is no significant correlation between IL-10 -1082 A and AA of allele and genotype, respectively in tuberculosis patients (p > 0.05) was evident. Conclusion. From our finding, the genetic variability of TNF-α -308 A and IFN-γ +874 alleles are the potent host genetic risk factors associated with tuberculosis infection.

<p class="abstract"><strong>Background:</strong> Survey data in Sub-Saharan African countries in the 2005 to 2010 period showed that only 10% men and 15% women aged 15 to 24 years were aware of their human-immunodeficiency virus (HIV) status. This study aims to assess: magnitude of HIV testing, and socio demographic factors associated with it among adults age 15-49 years.</p><p class="abstract"><strong>Methods:</strong> Demographic and health surveys in 2016, in Ethiopia were analyzed in SPSS, using multivariate logistic regression. We used HIV testing as the outcome variable using the recommended definition by Ethiopia demographic and health survey (EDHS) 2016. Descriptive statistics were employed to show the distribution of socio-demographic characteristics.  </p><p class="abstract"><strong>Results:</strong> Of the total sample of 27289 of men and women 15-49 years at the time of survey, 19.4% (n=5295) have been tested for HIV in the past 12 months and received the results of the last test. Men and women in the 15-19 age group 9.952 (AOR 9.95295% CI 6.156-16.091) and men and women age 15-49 years in urban areas (AOR 34.040; 95% CI: 21.028-55.105) were found significant predictors of HIV testing.</p><p class="abstract"><strong>Conclusions:</strong> HIV testing among adults age 15-49 years in Ethiopia was low. Age and place of residence were found significant predictors of HIV testing there remain a high proportion of undiagnosed HIV-infected persons and for the Ethiopian government there is a need for innovative strategies aimed at increasing HIV-testing, particularly for rural areas and those beyond adolescent age.</p>

The aim of this systemic review and meta-analysis was to examine the relationship between iron with folic acid supplementation and low birth weight in Ethiopia Previous studies on iron with folic acid supplementation and low birth weight indicated different findings. We include 24 studies in different regions of Ethiopia. We have done this study focusing on iron with folic acid supplementation Materials and Methods The databases searched were PUBMED and Advanced Google Scholar. on reference manager software reporting iron with folic acid supplementation and low birth weight. Three researchers were carried out the data extraction and assessed independently the articles for inclusion in the review using risk-of-bias tool guided by PRISMA checklist. The combined adjusted Odds ratios (OR)) and 95% confidence intervals were calculated using random effect model Results: Twenty-four observational studies involving 10 989 participants, 2348 newborns have low birth weight were included. The combined effect size (OR) for low birth weight r comparing women who have iron with folic acid supplementation versus women who did not have iron with folic acid supplementation was 0.37 (95%CI 0.25 to 0.55), p<0.00001, I 2 = 91 %). There was significant heterogeneity (Q = 264.75. I 2 =91 %). p<0.00001) No publication bias was observed (Egger's test: p = 0.621, Begg's test: p = 0.254). 71.11% (7815), women reported iron with folic acid supplementation during current pregnancy in all studies, the proportion of low birth weight among women reported iron with folic acid supplementation during current

The purpose of this meta-analysis was to assess the association between Depression and suicidal ideation. We use data from six studies to do a meta-analysis. We applied the random-effects analytic model and calculated a pooled odds ratio. The combined effect size showed that odds of suicidal ideation among people with Depression is 4.88 times higher than those peoples without Depression (ORMH 4.88 95%CI 2.04, 11.72) Test for overall effect: Z = 3.55 (P = 0.0004) Heterogeneity: Tau² = 1.11; Chi² = 100.97, df = 5 (P < 0.00001); I² = 95%. The magnitude of suicidal ideation among people with Depression is 46.39% (528) and peoples without Depression is 17.79 % (315) from the total, 39.13 % (1138) is depressed and 60.86% (1779) not depressed. The overall proportion of Suicidal Ideation among the included studies is 28.98 % (843). The total number of study subjects included in our systematic review and meta-analysis is 2908.

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