Background: Several types of oral antidiabetic drugs (OADs), with or without insulin, may be used to achieve glycemic control in patients with type 2 diabetes mellitus (T2DM). However, real-life studies assessing diabetes treatments in Morocco are rare. Our aim was to assess the efficacy of various antidiabetic treatment regimens to achieve glycemic control in patients with uncontrolled T2DM, to determine the factors associated with a lack of glycemic control and to compare the clinical outcome after 26 weeks of treatment in a real-life setting.
Background:The aim of the study was to assess the real-life efficacy and safety of insulin glargine (Lantus ® , Sanofi) as a basal regimen in patients with type 2 diabetes mellitus (T2DM) who are poorly controlled with oral antidiabetic drugs (OADs) and/or other insulins.Methods: This observational, multicenter study was carried out in Morocco in 2011 and included 497 adult patients with T2DM and a baseline glycated hemoglobin (HbA1c) between 7.5% and 10.5% and for whom a basal regimen with insulin glargine was initiated. Two follow-up visits were scheduled at 12 and 26 weeks after starting treatment. The primary outcome target was HbA1c < 7%. Safety was assessed by the frequency of hypoglycemic episodes.
Results:The target HbA1c level of < 7% was reached by 11.5% of patients after 3 months of insulin glargine treatment and 32% after 6 months. Mean HbA1c decreased significantly from 9.37±1.14% at baseline to 7.43±0.87% at 6 months (P < 0.001). Mean fasting blood glucose also decreased significantly from 237.5 ± 66.9 mg/dL at baseline to 129.5 ± 35.1 mg/dL at 6 months (P < 0.001). Approximately 12% of patients reported at least one hypoglycemic episode. No adverse event other than hypoglycemia was reported.
Conclusions:This study shows that in a real-life setting, a basal regimen with insulin glargine significantly improves glycemic control in patients with T2DM who are inadequately controlled with OADs or other insulin regimens, with an acceptable hypoglycemia profile.
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