Voltammetric behaviors of Copper (II) nitrogen bearing nucleobases, such as Guanine (C5H4N5O2) was studied in electro analyzer using cyclic voltammetry (CV) on a Glassy Carbon Electrode. Assessment of the chemical and physical conditions that may favor optimum current enhancement was done by studying the effect of variation of concentration of metal and ligand ions, variation of scan rate, variation of step height, variation of pH values, and variation of supporting electrolyte as (NH4)2SO4, KCl, and NaCl. It was observed that Copper and Guanine forms a 1 : 2 ratio complex. The work reflects that increasing the concentration of either metal ion or ligand ion increases the corresponding current. Increasing the scan rate increases the corresponding current linearly with the square root of the scan rate. As the step height decreases the peaks become sharp. Anodic and cathodic current increases linearly with decreasing step height. For the complex mixture the complexation occurs maximum at a pH of 2.3–7.0 and is badly restricted in the slightly alkaline medium and the complexing order of the supporting electrolyte showed a trend as (NH4)2SO4>NaCl>KCl.
Introduction: The most affordable tablet form is microcrystalline cellulose (MCC), a popular pharmaceutical excipient that is utilized as a filler or binder in immediately compressible tablets. Methods: In the present study, we extracted dissolving cellulose from jute fibers by treatment with 0.1 N hydrochloric acid solution and 20% w/w sodium hydroxide solution at high temperature and pressure. The dissolving cellulose was subjected to acid hydrolysis at 100 0C for 2 h with 2 N hydrochloric acid. The identity of the MCC was confirmed by FT-IR and by determining the degree of polymerization. To evaluate the flow property, we determined the bulk, density, tapped density, Hausner index, Carr’s index and angle of repose. The tableting property of the prepared MCC was evaluated by making fexofenadine hydrochloride tablets.
Result and Discussion: The dissolving cellulose contains 94.67% α-cellulose The DP of the MCC was found 191. The powder properties such as bulk density, tapped density, Hausner index and Carr’s index, angle of repose values are comparable with that of standard Avicel PH102. The hardness, friability, disintegration time and % dissolved in 30 minutes were dissolution value of the tablets 5.6 kg, 0.34%, 178.17 sec and 83.89%, respectively. All these values are within the United State Pharmacopoeia range and are comparable with the tablets prepared from Avicel PH102 and marketed fexofenadine tablets.
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