Endophytic fungi are microorganisms that exist almost ubiquitously inside the various tissues of living plants where they act as an important reservoir of diverse bioactive compounds. Recently, endophytic fungi have drawn tremendous attention from researchers; their isolation, culture, purification, and characterization have revealed the presence of around 200 important and diverse compounds including anticancer agents, antibiotics, antifungals, antivirals, immunosuppressants, and antimycotics. Many of these anticancer compounds, such as paclitaxel, camptothecin, vinblastine, vincristine, podophyllotoxin, and their derivatives, are currently being used clinically for the treatment of various cancers (e.g., ovarian, breast, prostate, lung cancers, and leukemias). By increasing the yield of specific compounds with genetic engineering and other biotechnologies, endophytic fungi could be a promising, prolific source of anticancer drugs. In the future, compounds derived from endophytic fungi could increase treatment availability and cost effectiveness. This comprehensive review includes the putative anticancer compounds from plant-derived endophytic fungi discovered from 1990 to 2020 with their source endophytic fungi and host plants as well as their antitumor activity against various cell lines.
Disinfectants have been used largely in hospitals, health care centers and different pharmaceuticals for the removal of microorganisms. It is evident that microorganisms are showing reduced sensitivity against many disinfectants or their minimum inhibitory concentration (MIC) is increasing day by day due to improper use. The aim of this study was to compare the reduced susceptibility to disinfectants and antibiotics of 25 hospital isolates of Pseudomonas aeruginosa and 40 hospital isolates of Staphylococcus aureus isolated from 5 different hospitals at Noakhali region of Bangladesh. Susceptibility of the selected isolates to two disinfectants (savlon and herpic) and ten separate antimicrobial agents for both P. aeruginosa and S. aureus were investigated and compared. Multidrug resistant pattern of all the hospital isolates were determined by agar diffusion method and MIC of the disinfectants were determined by the serial dilution method. All the hospital isolates of P. aeruginosa and S. aureus were multidrug resistant. No severe evident resistance to disinfectants was seen among the 25 isolates of P. aeruginosa and 40 isolates of S. aureus. Interestingly, satisfactory MIC of savlon for 25 isolates of P. aeruginosa and 40 isolates of S. aureus reached at 0.5% to 0.7% (v/v) solution whereas satisfactory MIC of herpic reached at 2% to 2.5% (v/v) solution for all hospital isolates but four isolates of S. aureus showed MIC against herpic at 1.75% (v/v) solution. No sign of co-resistant of disinfectant and antibiotics were found. So, it can be concluded that disinfectants (savlon and herpic) can't be responsible for P. aeruginosa and S. aureus to become multidrug resistant, when the semi inhibitory dilution of these disinfectants are used. Keywords: disinfectants, multidrug resistant, P. aeruginosa, S. aureus ÖZET Bangladeş'teki hastanelerde toplanan Pseudomonas aeruginosa ve Staphylococcus aureus izolatlarında bulunan dezenfektanlara karşı azaltılmış duyarlılık ve çoklu ilaca direnç gelişimi arasında karşılaştırma Amaç: Mikroorganizmaların giderilmesini sağlamak amacıyla hastaneler ve sağlık tesislerinde dezenfektanlar ve çeşitli tür ilaçlar kullanılmaktadır. Bilindiği gibi uygunsuz kullanımdan dolayı mikroorganizmaların dezenfektanlara karşı gösterdiği duyarlılık azalıyor ya da minimum engelleyici konsantrasyonu (MEK) günbegün artıyor. Çalışmamız, Bangladeş'in Noakhali bölgesinde bulunan 5 hastaneden alınan 25 tane Pseudomonas aeruginosa ve 40 tane Staphylococcus aureus hastane izolatlarında, dezenfektanlara ve antibiyotiklere karşı gelişen azaltılmış direnç derecelerini karşılaştırmayı amaçladı. Seçilmiş olan P. aeruginosa ve S. aureus izolatlarının iki dezenfektan (Savlon ve Harpic) ve on tane farklı antimikrobiyal ajana karşı gösterdiği duyarlılıklar araştırılıp karşılaştırıldı. Bütün hastane izolatlarının çoklu ilaca direnç kalıpları, agar diffüzyon yöntemi kullanarak saptanıp dezenfektanların MEK'leri seri seyreltme yöntemiyle bulundu. Hem P. aeruginosa hem de S. aureus'un bütün hastane izolatları çoklu...
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