Sustained success in the new organizations depends on the creation, sharing and applying knowledge as an intellectual capital. Among various organizational factors, organizational commitment and its relationship with knowledge sharing had less been considered. This study investigated the relationship between organizational commitment and knowledge sharing from the perspective of Shiraz University of Medical Sciences (SUMS) faculties. Organizational commitment includes affective, normative and continuous commitment. The research was descriptive-correlation. The sample consisted of 122 cases of SUMS faculties selected by simple random sampling. The research instruments were Meyer and Allen Organizational Commitment and MANDI Knowledge Sharing Questionnaires. The results revealed a positive correlation between organizational commitment and its dimensions and knowledge sharing. The affective, normative and continuous commitment can predict knowledge sharing, respectively. The only significant positive relationship between demographic variables and the main variables were related to the emotional level of service and commitment.