-Blinking is a normal human phenomenom involving trigeminal and facial patways. To gain understanding on the neurobiology of blinking, five normal subjects were investigated before and after a pplication of transdermal capsaicin at the forehead for two weeks. No effects of topical capsaicin were detected in eye blink rates. However, when capsaicin was applied to a female subject with blepharospasm, s h e showed a dramatic restoration of her vision subsequent to blinking modification. Deactivation of abnormal A-to-C fibers cross talks at the trigeminal-facial pathways seems to be the most likely mechanism of such improvement.KEY WORDS: capsaicin, visuomotor integration, C-fibers, blinking, dystonia.Efectos de la capsaicina en el parpadeo RESUMEN -El parpadeo es un fenómeno normal en los humanos que involucra las vías trigéminas faciales. Con el fin de conocer un poco más la neurobiología de este fenómeno estudiamos cinco individuos norm ales antes y después de aplicar capsaicina trasdérmica en la frente de cada uno de ellos, por dos semanas. La frecuencia de parpadeo no se alteró con la aplicación de capsaicina tópica. Sin embargo, cuando la misma sustancia se aplicó a una paciente con blefaroespasmo hubo dramática restauración de su visión, la cual fue secundaria a la modificación de la actividad muscular palpebral. La desactivación del cruce patológi-co de información que pasa de las fibras A a las fibras C, pertenecientes a las vías trigémino-faciales, pare c e ser el mecanismo de acción relacionado con la aplicación de capsaicina, el que estaría directamente re l a c i o n ado con la recuperación clínica observada en la paciente con blefaroespasmo.
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