Background:The tumor suppressor gene HIC1 (hypermethylated in cancer 1) encodes a transcriptional repressor SUMOylated at Lys-314. Results: DNA damage favors SUMOylation of HIC1 and its interaction with MTA1 to regulate the DNA repair process. Conclusion: Our results demonstrate that HIC1 is implicated in the DNA damage response. Significance: Our work could help explain a mechanism whereby HIC1 loss contributes to tumorigenesis.
Background: HIC1 is a transcriptional repressor recruiting CtBP and NuRD complexes. Results: HIC1 interacts with human Polycomb-like proteins. Conclusion: HIC1 recruits the Polycomb PRC2 on a subset of its target genes through interactions with Polycomb-like proteins. Significance: Our results implicate hPCL proteins in the recruitment of PRC2 by transcription factors in mammals.
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