Recent results of the searches for Supersymmetry in final states with one or two leptons at CMS are presented. Many Supersymmetry scenarios, including the Constrained Minimal Supersymmetric extension of the Standard Model (CMSSM), predict a substantial amount of events containing leptons, while the largest fraction of Standard Model background events -which are QCD interactions -gets strongly reduced by requiring isolated leptons. The analyzed data was taken in 2011 and corresponds to an integrated luminosity of approximately L = 1 fb −1 . The center-of-mass energy of the pp collisions was √ s = 7 TeV.

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. Here we report the identification of three variants in the RUNX3, LTBRTNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10−8 in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10−6 overall, with support in each of the three datasets studied). We also show that polymorphisms of ERAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA class I presentation, only affect ankylosing spondylitis risk in HLA-B27–positive individuals. These findings provide strong evidence that HLA-B27 operates in ankylosing spondylitis through a mechanism involving aberrant processing of antigenic peptides.

The DØ experiment enjoyed a very successful data-collection run at the Fermilab Tevatron collider between 1992 and 1996. Since then, the detector has been upgraded to take advantage of improvements to the Tevatron and to enhance its physics capabilities. We describe the new elements of the detector, including the silicon microstrip tracker, central fiber tracker, solenoidal magnet, preshower detectors, forward muon detector, and forward proton detector. The uranium/liquid-argon calorimeters and central muon detector, remaining from Run I, are discussed briefly. We also present the associated electronics, triggering, and data acquisition systems, along with the design and implementation of software specific to DØ.

We performed a genome-wide association scan in 1461 patients with bipolar (BP) 1 disorder, 2008 controls drawn from the Systematic Treatment Enhancement Program for Bipolar Disorder and the University College London sample collections with successful genotyping for 372 193 single nucleotide polymorphisms (SNPs). Our strongest single SNP results are found in myosin5B (MYO5B; P = 1.66 Â 10 À7 ) and tetraspanin-8 (TSPAN8; P = 6.11 Â 10 À7 ). Haplotype analysis further supported single SNP results highlighting MYO5B, TSPAN8 and the epidermal growth factor receptor (MYO5B; P = 2.04 Â 10 À8 , TSPAN8; P = 7.57 Â 10 À7 and EGFR; P = 8.36 Â 10 À8 ). For replication, we genotyped 304 SNPs in family-based NIMH samples (n = 409 trios) and University of Edinburgh case-control samples (n = 365 cases, 351 controls) that did not provide independent replication after correction for multiple testing. A comparison of our strongest associations with the genome-wide scan of 1868 patients with BP disorder and 2938 controls who completed the scan as part of the Wellcome Trust Case-Control Consortium indicates concordant signals for SNPs within the voltage-dependent calcium channel, L-type, alpha 1C subunit (CACNA1C) gene. Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection.

Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control association study involving 10,619 individuals with ankylosing spondylitis (cases) and 15,145 controls. We identified 13 new risk loci and 12 additional ankylosing spondylitis–associated haplotypes at 11 loci. Two ankylosing spondylitis–associated regions have now been identified encoding four aminopeptidases that are involved in peptide processing before major histocompatibility complex (MHC) class I presentation. Protective variants at two of these loci are associated both with reduced aminopeptidase function and with MHC class I cell surface expression.

The corrosion of metals is one of the main destructive processes that leads to huge economic losses. Polymer coating systems are normally applied on a metal surface to provide a dense barrier against the corrosive species in order to protect metal structures from corrosive attack. When the barrier is damaged and the corrosive agents penetrate to the metal surface the coating system can not stop the corrosion process. The most effective solution so far for designing anticorrosion coatings for active protection of metals is to employ chromate-containing conversion coatings.[1] However, hexavalent chromium species are responsible for several diseases, including DNA damage and cancer, [2] which is the main reason for banning Cr 6+ -containing anticorrosion coatings in Europe from 2007. The deposition of thin inorganic or hybrid films on metallic surfaces has been suggested as a pretreatment to provide an additional barrier against the corrosion species and mainly to improve adhesion between the metal and polymer coating system.[3] The films are usually deposited by the plasma polymerization technique or the sol-gel route. Sol-gel-derived thin films that contain either inorganic (phosphates, vanadates, borates, and cerium and molybdenum compounds) or organic (phenylphosphonic acid, mercaptobenzothiazole, mercaptobenzoimidazole, triazole) inhibitors are investigated as substitutes for chromates. [3a-e] Among them, the highest activity is shown for sol-gel coatings with a cerium dopant of a critical concentration in the 0.2-0.6 wt % range. However, the negative effect of the free inhibitor occluded in the sol-gel matrix on the stability of the protective film is observed for all types of inhibitors (for instance, a higher concentration of Ce leads to the formation of microholes in the sol-gel film [3f] ). This shortcoming calls for the development of nanometer-scale reservoirs to isolate an inhibitor inside and prevent its direct interaction with the sol-gel matrix. Nanoreservoirs should be homogeneously distributed in the film matrix and should possess controlled and corrosion-stimulated inhibitor release to cure corrosion defects.Mixed-oxide nanoparticles (e.g. ZrO 2 /CeO 2 ), [4] b-cyclodextrin-inhibitor complexes, [3c] hollow polypropylene fibers, [5] and conducting polyaniline [6] have been explored as prospective reservoirs for corrosion inhibitors to be incorporated in the protective film. The common mechanism of the nanoreservoir activity is based on the slow release of inhibitor triggered by corrosion processes. Ion exchangers have also been investigated as 'smart' reservoirs for corrosion inhibitors. Chemically synthesized hydrocalmite behaves as an anion exchanger: adsorbing corrosive chloride ions and releasing corrosion-inhibiting nitrite anions. [7] Despite considerable efforts devoted to the development of new, complex anticorrosion systems, practically no single solution is able to fulfill the requirements of sufficient corrosion protection while avoiding chromates in the coating, especially in the ...

Copyright and reuse:Sussex Research Online is a digital repository of the research output of the University.Copyright and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable, the material made available in SRO has been checked for eligibility before being made available.Copies of full text items generally can be reproduced, displayed or performed and given to third parties in any format or medium for personal research or study, educational, or not-for-profit purposes without prior permission or charge, provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way.Article accepted for publication in Journal of Experimental Psychology: General. http://dx.doi.org/10.1037/xge0000175 © American Psychological Association (APA) This article may not exactly replicate the authoritative document published in the APA journal. It is not the copy of record. contrast between independence and interdependence does not adequately capture the diverse models of selfhood that prevail in different world regions. Cultural groups emphasize different ways of being both independent and interdependent, depending on individualism-collectivism, national socioeconomic development, and religious heritage. Our seven-dimensional model will allow future researchers to test more accurately the implications of cultural models of selfhood for psychological processes in diverse ecocultural contexts.Keywords: CULTURE; SELF-CONSTRUALS; INDEPENDENCE-INTERDEPENDENCE Twenty-five years ago, Markus and Kitayama (1991) published their classic article on culture and the self, proposing that people in different parts of the world tend to construe themselves in two fundamentally different ways. They argued that Western cultures are unusual in promoting an independent view of the self as bounded, unitary, stable, and separate from the social context, whereas cultures in other parts of the world emphasize an interdependent view of the self as closely connected to others, fluid, and contextually embedded. They proposed that people with independent self-construals would strive for self-expression, uniqueness, and self-actualization, basing their actions on personal thoughts, feelings, and goals. In contrast, people with interdependent self-construals would strive to fit in and maintain social harmony, basing their actions on situationally defined norms and expectations.Markus and Kitayama's (1991) proposals had a dramatic impact on social, personality and developmental psychology, challenging ethnocentric assumptions, drawing attention to cultural diversity, and providing conceptual tools for theorizing about it. Social and personality psychologists used measures and manipulations of self-construals to predict numerous outcomes: cognitive styles, well-being, self-regulation, selfesteem, communication styles, social anxiety, and pro...

The layer-by-layer molecular-level manipulation of conjugated polyions has been successfully utilized to fabricate ultrathin multilayer films and multilayer heterostructures. Through a process involving the alternate spontaneous adsorption of oppositely charged polymers from dilute aqueous solutions, multilayer thin films were fabricated from a variety of different bilayer combinations including conjugated/nonconjugated polyion bilayers, conjugated/conjugated polyion bilayers, and precursor polymer/ conjugated polyion bilayers. UV-vis absorbance measurements revealed that in all cases the bilayer deposition process was linear and highly reproducible from layer to layer. Kinetic studies showed that the equilibrium adsorption of a polyion layer is reached within about 10 min and the process can be carried out onto different substrate surfaces. The typical bilayer thickness ranges from approximately 10 to 25 Á and can be readily controlled by variations in such parameters as solution concentration, pH, doping level, and ionic strength.Multilayer thin films are prepared by simply repeating this basic bilayer deposition process. As long as the substrate is alternately dipped into a polycation solution and a polyanion solution, multilayer thin films with