RESUMO:O objetivo deste estudo foi investigar a interferência da fração polar e apolar, bem como do óleo essencial da Baccharis dracunculifolia DC., Asteraceae, sobre o efeito de antibióticos utilizados na clínica médica. Os ensaios foram realizados com vinte e nove antibióticos em associação com os dois extratos [uma fração polar (HA 50%) e uma da fração apolar (EA 25%)] e com o óleo essencial. O método utilizado foi o método de difusão em meio sólido utilizando os discos de antibióticos, adquiridos comercialmente. Os resultados mostraram interferência na ação esperada do antibiótico quando associado aos extratos e ao óleo essencial da B. dracunculifolia. Em alguns casos não houve alteração da ação do antibiótico, no entanto, na maioria dos casos houve interferência sinérgica ou antagônica da ação do antibiótico. Estes resultados mostram que o uso de produtos derivados de plantas pode em algumas situações interferir sobre a efetividade de antibióticos de uso no tratamento clínico.Unitermos: Plantas medicinais, óleos essenciais, antibióticos, uso associado, interferência, Baccharis drancunculifolia.ABSTRACT: "Interference from extracts of Baccharis dracunculifolia DC., Asteraceae, on the activity of antibiotics used in the clinic". The objective of this study was to investigate the interference of the polar and apolar fraction as well the essential oil of Baccharis dracunculifolia DC., Asteraceae, about the antibiotics effects used in the medic clinic. The essays were accomplished with twenty nine antibiotics in association with two extracts [one polar fraction (HA 50%) and one of apolar fraction (EA 25%)] and with essential oil. The method used was the diffusion one in solid mean using the antibiotic discs, which were acquired commercially. The results showed interference in the hoped action of the antibiotic when associated to the extract and to the B. dracunculifolia essential oil. In some cases there was no alteration of the antibiotic action, however, in most of the cases there was either a synergic or an antagonic interference of the antibiotic action. These outcomes have showed that the use of derived products or plants can interfere on the effectiveness of the antibiotic use in the clinic treatment, in some situations. ISSN 0102-695X Keywords INTRODUÇÃOAs plantas medicinais e os fitoterápicos apresentam papel importante na terapêutica, pois 25% dos medicamentos prescritos mundialmente são de origem natural (OMS, 1991;Rates, 2001) e constituem uma importante fonte de novos compostos biologicamente ativos. Elas aparecem como parte do cuidado tradicional de saúde em muitas partes do mundo ao longo de décadas e têm despertado o interesse de vários pesquisadores (Ceballos et al., 1993;Lima, 1996;Cunha, 1995;Cowan, 1999;Farias & Lima, 2000;Belém, 2002;Michelin et al., 2005). Na medicina popular, as plantas são utilizadas concomitantemente ao uso de medicamentos convencionais (Amorim, 1999). Neste uso associado, as plantas medicinais e/ou seus subprodutos podem atuar inibindo ou intensificando o efeito terapêut...
The aim of this study was to investigate the effects of Baccharis coridifolia essential oil on the Activity of Antibiotics. Assays were performed with ampicillin (10 μg), cephalothin (30 μg), chloramphenicol (30 μg), gentamicin (10 μg) and tetracycline (30 μg) alone and in combination with the essential oil (4% v/v) through the disk diffusion susceptibility test. The results showed the effects of essential oil on the activity of the antibiotics tested. Zones of inhibition of bacterial growth with different diameters were observed surrounding the antibiotic disks, whether or not they were impregnated with the essential oil. The occurrence of the synergistic or antagonistic effect was observed in both bacterial strains assessed-Staphylococcus aureus (ATCC-25923) and Escherichia coli (ATCC-25922). These results show that the use of products derived from plants can, in some cases, interfere with the effectiveness of antibiotics during clinical therapy.
The family Asteraceae is the most numerous group within the Angiosperms. Plants from this family are studied for their chemical co mposition and biological act ivity. In these studies, the allelopathic, antimicrobial, cytotoxic and anti-inflammatory effects are highlighted. The aim of this study was to evaluate the action of the aqueous (AF1) and the oily (OF2) fract ions obtained fro m the ethanol extract of Baccharis coridifolia D. C. on the antimicrobial act ivity of antib iotics used in clinical treat ment. The drugs chloramphenicol (30 µg), norflo xacin (10 µg), sulfametho xazole / trimethoprim (75/23 µg), vancomycin (30 µg) and amo xicillin (10 µg) were saturated with the fractions AF1 and OF2, and used pure for further comparison. The strains Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923 were used. The results showed that both fractions interfered on the activity of the antibiotics tested. Synergistic, antagonistic or indifferent behavior was observed in the interactions, with various degrees of susceptibility to the antib iotics tested. These results show that the use of products derived fro m plants can, in some cases, interfere with the effectiveness of antibiotics during clin ical therapy.
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