A hybrid bioinspired material with manganese(II) complexes grafted on the surface of a mesostructured porous silica is investigated. The Mn sites mimic the manganese-dependent dioxygenase (MndD), which is an enzyme that catalyses the oxidation of catechol derivatives. The metal complexes were introduced in the silica using a dinuclear complex [Mn 2 L 2 (Cl) 2 (m-Cl) 2 ] as a precursor with a clickable ligand N,N 0 -bis. Azide moieties covalently grafted on MCM-41 type mesoporous silica were utilised to anchor the manganese complex through Huisgen cycloaddition using CuBr(PPh 3 ) 3 as a catalyst. A second functional group -trimethylsilyl or pyridine-was grafted on the silica to bring, together with nanopore size confinement, a similar metal environment as in MndD. The mesostructure of the materials was maintained after incorporation of the Mn complex. Catalytic oxidation of 3,5-di-t-butyl-catechol (3,5-DTBC) into quinone occurred without the need of an additional base when the metal complex was confined in the porous solid. In comparision, the oxidation of 4-tbutyl-catechol (4-TBC) that always required a basic media led to a total oxidation into the orthoquinone, contrary to the molecular analogue.
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