Four novel polyketide-derived metabolites, myriaporones 1, 2, 3, and 4, have been isolated from the Mediterranean bryozoan Myriapora truncata. Their structures and stereochemistry have been assigned from the analysis of spectroscopic data. The inseparable equilibrium mixture of myriaporones 3 and 4 showed 88% inhibition of L1210 murine leukemia cells at 0.2 microg/mL.
A novel treatment approach to address the nasolabial fold is the insertion facial suspension threads. However, there is a paucity of data available to guide insertion techniques and material selection. Three female and two male cephalic specimens of Caucasian ethnicity (73.6 ± 6.5 years; 21.41 ± 2.2 kg/m2) were included into this experimental split-face study. One facial side was treated with polycaprolactone (PCL) thread: 180 mm, bidirectional, 18G 100 mm cannula, 20 degrees trajectory, preauricular approach whereas the contralateral side was treated with polydioxanone (PDO) thread: 100 mm, bidirectional, 19G, 60 mm cannula, 50 degrees trajectory, infraorbital approach. Three-dimensional imaging outcome measures included vertical and horizontal skin displacement and volume changes at the nasolabial sulcus, at the labiomandibular sulcus, and along the jawline. Comparing PCL 180 mm 20 degrees to PDO 100 mm 50 degrees: vertical lifting effect 1.42 ± 2.63 mm versus 1.24 ± 1.88 mm (p = 0.906); horizontal lifting effect 3.42 ± 1.44 mm versus –2.02 ± 1.84 mm (p = 0.001); nasolabial volume change –0.80 ± 0.65 mL versus –0.52 ± 0.17 mL (p = 0.367); labiomandibular volume change –0.45 ± 0.42 mL versus –0.16 ± 0.16 mL (p = 0.191); jawline volume change 0.02 ± 0.43 mL versus –0.01 ± 0.21 mL (p = 0.892). The study provides objective evidence for the short-term effectiveness of facial suspension threads in treating the nasolabial folds. The results point toward a better aesthetic outcome when utilizing long facial suspension threads that can effect full-face changes as compared with short facial suspension threads.
ResumoAmbientes corporativos compreendem uma grande diversidade de atividades, com suas especificidades. A partir das etapas do método de Bonsiepe (1984), além de ferramentas de outros métodos, o presente artigo, trata da descrição de um conjunto de pesquisas e análises que resultaram em um quadro de requisitos e parâmetros. A estrutura tem por finalidade adequar um ambiente corporativo às demandas apresentadas pelos usuários, e agregá-las aos princípios sustentáveis. Com os resultados especificados, foi possível compreender, estruturar e aplicar, medidas e condições de melhorias alinhadas às necessidades identificadas para o ambiente administrativo da Universidade Federal da Paraíba. O projeto priorizou a redução de materiais que provoquem impactos ambientais.Palavras Chave: Requisitos projetuais; Design de interiores; Sustentabilidade.
AbstractCorporate environments comprise a great diversity of activities, with their specificities. Following the steps of the method of Bonsiepe (1984), as well as tools from other methods, this article deals with the description of a set of researches and analyzes which has resulted in a table of requirements and parameters. The work aims to adapt a corporate environment to the demands presented by users, and to add them to the sustainable principles. With the specified results, it was possible to understand, structure and apply, measures and improvement conditions aligned with the needs identified for the administrative environment of the Federal University of Paraíba. The project prioritized the reduction of materials that provoke environmental impacts 13º Congresso Brasileiro de Pesquisa e Desenvolvimento em Design, Univille, Joinville (SC) 05 a 08 de novembro de 2018 Segundo Mancuso (2010), demorou bastante tempo para que os ambientes de caráter comercial fossem vistos como locais em que deveria haver a interferência de arquitetos ou designers de interiores. E ainda segundo a autora:Em todo o século XIX a até meados do século XX a arquitetura de interiores praticamente não existia, os ambientes comerciais como restaurantes, consultórios e até lojas eram decorados por seus próprios proprietários. Era muito comum ver antigas casas serem transformadas em clínicas ou restaurantes com a simplicidade da abertura de uma parede ou a locação de uma vitrine em sua fachada (MANCUSO, 2010, p. 101). 13º Congresso Brasileiro de Pesquisa e Desenvolvimento em Design, Univille, Joinville (SC) 05 a 08 de novembro de 2018
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