We report neutralizing antibody titers (NAbTs) elicited by CoronaVac and BNT162b2 vaccines in healthcare workers with and without prior SARS-CoV-2 infection using both a pseudotype-based assay and a commercial kit. NAbTs were higher for the mRNA vaccine and increased in all previously infected. Good correlation between both assays was found.
Our hospital is a tertiary/teaching hospital located in a city with 767 beds that transfuses approximately 33,000 units of red blood cells (RBCs) each year.Question 2 a. The transfusion service policy defines a massive transfusion event (MTE) as 'a situation in which a large number of blood products are expected to be transfused in a short amount of time'. This may include adult patients who have 8-10 units replaced in 6 h or when the transfused volume equals the patient's total blood volume. This policy definition is designed to help providers identify situations in which it may be appropriate to active an MTE. This policy applies to all clinical settings in our hospital but does not exclude clinical areas from having their own definition. There are no separate definitions for MAJOR TRANSFUSION, MASSIVE TRANSFUSION and SUPRA-MASSIVE TRANSFUSION in adults. There may be some benefit to distinguishing extremely high-volume transfusions if that resulted in differentiation of treatment (i.e., use of whole blood [WB], tranexamic acid [TXA] and prothrombin complex concentrates [PCCs]). b. We have adopted a policy designed to implement early inclusion of plasma in a 1:1 ratio with RBCs. The policy applies across all settings. c. The MTE guidelines exist in a formal policy that is reviewed and updated at least every 2 years but is often updated more frequently to reflect current best practices. Policy changes are proposed and reviewed by transfusion medicine physicians and a multidisciplinary transfusion practice committee. d. No. Question 3 a. Our guidelines recommend a 1:1 ratio of red cells to plasma across settings. b. Our guidelines recommend a ratio of 1 apheresis platelet for every 6 red cells. c. Guidelines recommend fibrinogen replacement below 100 mg/dl across all settings. d. TXA is suggested as an adjunct treatment for massively transfused patients but is not part of the formal policy. Question 4 a. Selection is based on age and gender. Females under the age of 50 are given Rh-negative red cells. All other patients are given RhD-positive RBCs.
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