Overweight and obesity accompanies up to 70% of pregnancies and is a strong risk factor for offspring metabolic disease. Maternal obesity-associated inflammation and lipid profile are hypothesized as important contributors to excess offspring liver and skeletal muscle lipid deposition and oxidative stress. Here, we tested whether dams expressing the fat-1 transgene, which endogenously converts omega-6 (n-6) to omega-3 (n-3) polyunsaturated fatty acid, could protect wild-type (WT) offspring against high-fat diet induced weight gain, oxidative stress, and disrupted mitochondrial fatty acid oxidation. Despite similar body mass at weaning, offspring from fat-1 high-fat-fed dams gained less weight compared with offspring from WT high-fat-fed dams. In particular, WT males from fat-1 high-fat-fed dams were protected from post-weaning high-fat diet induced weight gain, reduced fatty acid oxidation, or excess oxidative stress compared with offspring of WT high-fat-fed dams. Adult offspring of WT high-fat-fed dams exhibited greater skeletal muscle triglycerides and reduced skeletal muscle antioxidant defense and redox balance compared with offspring of WT dams on control diet. Fat-1 offspring were protected from the reduced fatty acid oxidation and excess oxidative stress observed in offspring of WT high-fat-fed dams. These results indicate that a maternal fat-1 transgene has protective effects against offspring liver and skeletal muscle lipotoxicity resulting from a maternal high-fat diet, particularly in males. Altering maternal fatty acid composition, without changing maternal dietary composition or weight gain with high-fat feeding, may highlight important strategies for n-3-based prevention of developmental programming of obesity and its complications.

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features, higher rates of preterm birth in women without PNC persisted (aOR 2.65, 95%CI 1.95-3.55). Women without PNC resided in areas that relied more on public transportation and required longer transit times (42 min vs 30 min, P¼.005) with more bus stops (29 vs 17, P<.001) to the nearest county-sponsored PNC clinic (Figure). CONCLUSION: Women without PNC are at significantly increased risk for adverse pregnancy outcomes. In a large inner-city, women without PNC reside in areas with significantly higher demands for public transportation. Alternative resources, including telemedicine and ride-sharing, should be explored to reduce barriers to care.

point based risk score based only on the presence of model variables (0-1 low, 2-3 medium, and 4-5 high risk). RESULTS: Among 36,188 delivery admissions, there were 869 cases of SMM (2.4%). Gestational age was the best single variable predictor for SMM (AUC 0.62). Using our development sample, our final model was saturated at 4 variables: gestational age, obesity, preeclampsia, and a composite for bleeding risk (Table 1). This model performed moderately well at predicting risk for SMM (AUC 0.74). In our test sample, both probability and point based risk stratification discriminated SMM risk across low, medium, and high risk categories (Table 2, p< 0.001). CONCLUSION: Predicting delivery admissions at highest risk for SMM is feasible using a parsimonious point based risk stratification model. This model is practical to implement, can be used to inform hospital resource allocation, and is comparable in accuracy to existing risk tools for other obstetric outcomes.