Summary. 1. In its present form Dextrostix does not provide a reliable measure of blood glucose. 2. When modified and simplified it proved of great value in the management of diabetes in certain clinical situations. Dextrostix is an enzyme impregnated strip which gives an estimate of the blood glucose level one minute after the sample is taken. The strips are made of stiff, absorbent cellulose one end of which is impregnated with a buffered mixture of glucose oxidase, peroxidase and a chromagen system all coated with a semi permeable membrane. When a drop of capillary or venous blood is placed on the impregnated end of the strip for exactly one minute before being washed off with cold water, oxidation of the blood glucose occurs; the products of this reaction change the chromagen system to a blue color, the intensity of which varies with the concentration of glucose in the blood sample. The colour is then compared with the colour blocks provided by the manufacturers, from which the blood glucose value can be estimated. COgEN, LEGG and BIRD (1964) suggested that Dextrostix was accurate enough for most clinical situations, but agreement between Dextrostix and the laboratory results was less satisfactory at the extremes of the range. RENNIE, KEEN and SOUT~ON (1964) found that observer error was small, but that in the blood glucose range of 130--200 mg/100 m], the strip tended to give a falsely low estimate. RdsumgThe present study was undertaken to define the limits of reliability of Dextrostix, and to assess its clinical application.
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