Enzyme inhibiting activity X 0220Sulfonamide Chalcone as a New Class of α-Glucosidase Inhibitors. -Synthetic and purchased chalcones are tested for their enzymatic inhibitory activities against three glycosidases (α-glucosidase from baker's yeast, α-amylase from B. licheniformis, and β-amylase from barley). Sulfonamide chalcones (Ic)-(If) show strong inhibitory activity against α-glucosidase while aminated chalcones (Ia) and (Ib) exhibit mild inhibitory activity against β-amylase. In particular, sulfonamide chalcone (If) displays 150-fold stronger inhibitory activity than acarbose. -(SEO, W. D.; KIM, J. H.; KANG, J. E.; RYU, H. W.; CURTIS-LONG, M. J.; LEE, H. S.; YANG, M. S.; PARK*, K. H.; Bioorg. Med. Chem. Lett. 15 (2005) 24, 5514-5516; Dep. Agric. Chem., Gyeongsang Natl. Univ., Chinju 660-701, S. Korea; Eng.) -H. Hoennerscheid 11-235
Carbohydrates U 0500 α-Rhamnosidase Inhibitory Activities of Polyhydroxylated Pyrrolidine. -Design, synthesis, and α-rhamnosidase inhibitory activities of a series of polyhydroxylated pyrrolidines (I) (12 examples) are described. Pyrrolidine (Ib) shows the best inhibitory activity because it possesses the same stereoconfiguration at C1 and C2 as α-L-rhamnopyranoside. -(KIM, J. H.; CURTIS-LONG, M. J.; SEO, W. D.; LEE, J. H.; LEE, B. W.; YOON, Y. J.; KANG, K. Y.; PARK*, K. H.; Bioorg. Med. Chem. Lett. 15 (2005) 19, 4282-4285; Dep. Agric. Chem., Gyeongsang Natl. Univ., Chinju 660-701, S. Korea; Eng.) -R. Staver 51-175
Carbohydrates U 0500 Stereoselective Synthesis of L-Deoxyaltronojirimycin (VII) from L-Serine -[involving ring-closing metathesis and stereoselective epoxidation as key steps]. -(RENGASAMY, R.; CURTIS-LONG, M. J.; RYU, H. W.; OH, K. Y.; PARK*, K. H.; Bull. Korean Chem.
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