A 43-year-old woman of Mayan origin from Quintana Roo, Mexico, was diagnosed with diffuse lepromatous leprosy. The etiologic bacillus was determined to be Mycobacterium lepromatosis instead of Mycobacterium leprae. This case likely represents the first report of this leprosy form and its agent in the southeastern tip of Mexico. CASE REPORTA 43-year-old woman of Mayan ancestry sought dermatologic care in the town of Chetumal, Quintana Roo, Mexico. The patient complained of a 2-year history of burning skin sensation, loss of eyelashes and eyebrows, lower leg edema, and generalized weakness. She was a widowed housewife and had been previously healthy.Physical examination revealed generalized skin infiltration, including areas of prominent "peau d=orange" (erythematous and turgid appearance) and shining skin on the central face, cheeks, and chin. There was extensive loss of hair on arms, legs, and the pubic area. There were no eye lashes or eyebrows. The cornea reflex was diminished. The earlobes were enlarged and indurated. The body skin was dry and did not sweat. There was a generalized loss of sensation to needle pricks over the body. Laboratory examinations showed a normal hemoglobin level (140g/liter), normal counts of blood leukocytes (6.0 ϫ 10 9 / liter) and platelets, a negative VDRL test, a negative human immunodeficiency virus test, and a normal urine test. No thickened nerves were noted. Smears of the nasal mucosa and an earlobe showed acid-fast bacilli with intensities of ϩ and ϩϩ, respectively. These findings led to a working diagnosis of diffuse lepromatous leprosy (DLL) in view of the absence of skin nodules.A skin biopsy of the chin was performed. Histopathology showed extensive infiltration of histiocytes that involved skin appendages and a small nerve (Fig. 1). A Fite stain revealed moderate number of acid-fast bacilli in the skin tissue, with additional locations in the endothelia and a nerve (Fig. 2). These results rendered the diagnosis of DLL.The patient was treated with a multidrug regimen consisting of dapsone, rifampin, and clofazimine. In the third month of treatment, she developed weakness and red nodules on the face and arms, which was consistent with erythema nodosum leprosum. This mild reaction was controlled with 30 mg prednisone daily for 1 week with taper. Upon treatment for 12 months, nasal and earlobe smears remained positive for intact acid-fast bacilli, which led to continued treatment. The patient completed 18 months of treatment, resulting in negative smears and resolution of the skin infiltration and partial recovery of pain sensation, sweating, and hair (in the legs especially). At a 3-year follow-up, she showed nearly complete recovery of sensation and regrowth of hair on her eyelids and eyebrows. Thus, she was considered cured.The diagnosis of DLL prompted a quest to determine the identity of the acid-fast bacillus. Thus, differential PCRs were used to test the DNA extracted from the formalin-fixed paraffin-embedded biopsy tissue. The PCRs targeted the 16S rRNA genes of the...
La enfermedad del Covid-19 ocasionada por el virus SARS-CoV-2, es considerada de gran impacto por ser un problema de salud pública. Se conoce actualmente que Covid-19, es una enfermedad sistémica que puede afectar múltiples órganos y tejidos que puede ser fatal. La afectación hepática en relación a la Covid-19 se asemeja a cualquier daño hepático que ocurre durante el proceso de la enfermedad. El presente estudio tiene como objetivo Analizar las enfermedades hepáticas y Covid-19: un problema de salud pública a nivel mundial por el impacto presente en las enfermedades hepáticas como: Cirrosis, Esteatosis hepática, Hepatitis B y C, entre otros. Para el desarrollo del artículo se utilizó una investigación de tipo descriptivo y diseño bibliográfico y se procedió a investigar el objeto de estudio para describir la relación que existe entre las enfermedades hepáticas y Covid-19. Resultados: dentro de los estudios basados en artículos científicos y páginas web, se encontró relación entre las enfermedades hepáticas y Covid-19 en estos dos años de pandemia. En conclusión, se evidenció que existe una asociación entre las enfermedades hepáticas y la infección por Covid-19, prevaleciendo la hepatitis C con 61,40% y el Covid-19 con 46,2%, indicando las pruebas diagnósticas de laboratorio consideradas de gran importancia para la detección de enfermedades del hígado y Covid-19.
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