؉ NK cells exhibited a more functional profile, as detected by cytokine production and degranulation.
IMPORTANCE
We demonstrate that the frequency of highly functional CD8؉ NK cells is inversely associated with HIV-related disease markers and linked with delayed disease progression. These results thus indicate that CD8؉ NK cells represent a novel NK cell-derived, innate immune correlate with an improved clinical outcome in HIV infection.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.