MUC4 is expressed variably but almost consistently in meningiomas, particularly in meningothelial or angiomatous subtypes. Its immunohistochemical detection is useful to distinguish meningiomas from other intracranial or head and neck mesenchymal tumours, particularly those with epithelioid features. Our study could expand a variety of MUC4-positive mesenchymal tumours.
Prominent cyst formation is an unusual feature of liposarcoma. We report here a case of dedifferentiated liposarcoma with huge cystic change without preoperative chemo- or radiation therapy. The lesion arose in the retroperitoneum juxtaposed to the right kidney of a 67-year-old woman. She underwent a surgical removal of the retroperitoneal cyst. The cystic tumor contained 1600 mL of old bloody fluid, and its wall was composed of edematous, inflamed or sclerosing fibrous tissue with fatty tissue containing abundant atypical stromal cells, which were immunohistochemically positive for MDM2 and CDK4, and demonstrated MDM2 gene amplification by fluorescence in situ hybridization. The wall was contiguous to an atypical lipomatous nodule located in the mesentery. The following surgical specimens of the right hemicolectomy and right nephrectomy revealed atypical cells infiltrating into the subserosa of the colon and the perirenal fat tissue or that in the renal sinus. This case indicates that well differentiated or dedifferentiated liposarcoma should be also considered as a differential diagnosis of perirenal cystic mass.
Desmoplastic fibroblastoma (DFB) is an uncommon, benign, soft tissue tumor. The tumor most often presents as a slowly growing, painless soft tissue mass and is usually small. There have been only a few reports of patients with DFB who presented with bone invasion. Herein, we report the case of a 66-year-old woman with DFB with bone invasion in her left axilla. A lump under the left axilla was detected and was associated with pain and limited range of motion (ROM) of the shoulder. Computed tomography showed a soft tissue mass with invasion of the adjacent left humerus. Magnetic resonance imaging revealed a lesion with low signal intensity on T1- and T2-weighted images, and weak internal enhancement on postcontrast T1-weighted images with fat suppression. Histologic evaluation of a preoperative needle biopsy revealed DFB with FOSL1 expression. The tumor was marginally excised. Postoperative outpatient follow-up demonstrated a significant improvement in pain and ROM of the shoulder and no recurrence after 1 year. Even though DFB with bone invasion can cause pronounced clinical symptoms with pain and limited ROM, we conclude that simple excision is an adequate treatment.
Introduction Mucinous cystic neoplasms are uncommon among the tumors that develop in the retroperitoneum. We report a case of primary retroperitoneal mucinous cystadenocarcinoma with pathological considerations. Case presentation A 47‐year‐old woman complaining of abdominal discomfort presented at our hospital. Abdominal computed tomography and magnetic resonance imaging showed a large cystic tumor with small solid nodules located in the right retroperitoneum. The tumor was completely removed and the microscopic findings were consistent with primary retroperitoneal mucinous cystadenocarcinoma. Two years after the surgery, the patient is alive without recurrence of the tumor. Conclusion The microscopic findings suggested that the primary retroperitoneal mucinous cystadenocarcinoma developed from the metaplasia of the remnant coelomic epithelium. A complete tumor resection that includes the adjacent peritoneum is important to prevent local recurrence.
The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Letter to Editor transmural infarction of the small intestine. The most striking autopsy finding was a "coral-reef "-like structure in the aorta, occupying nearly half of the aortic surface, which consisted of groups of calcified grains, typically millet-to pea-sized konpeito 1-like spheroid nodules covered by tiny bulges (Fig. 1). Some nodules were isolated, and others were fused with each other. They were grey-white and slightly shiny. The surface was seemingly smooth, and there was no superficial thrombosis. The wall of the background aorta was hard because of dense calcifications. Histological examinations revealed "coral reef "like calcifications, consisting of protruding clusters of calcified nodules that bulged irregularly and had a convex luminal surface through a disrupted intima with a fractured calcific plate (Fig. 2a-f). The surface was covered by a thin or extremely thin cap lined with endothelium-like cells, generally accompanied by Acute coronary syndromes (ACS) are caused by thrombotic plaque disruption, including plaque rupture (65-70%), plaque erosion (25-30%), and calcified nodules (2-5%) 1). Although calcified nodules are the least frequent cause of ACS, they occur in the heavily calcified and tortuous arteries of older individuals 2). Despite this, it is unclear whether calcified nodules are a culprit of arterial thrombosis or whether they are just a bystander, which is not associated with overlying thrombosis. Here we present a unique case of "coral reef "-like aortic calcifications, characterized by communities of uncomplicated calcified nodules. A 71-year-old Japanese woman who had undergone graft replacement for aortic arch aneurysm and right femoral artery stenting was admitted to our hospital. She was on medication for hypertension. Plasma levels of LDL cholesterol, glucose, and creatinine were 90, 99, and 0.8 mg/dl, respectively. She died of acute Copyright©2020 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.
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