There is increasing evidence supporting the role of genetic variants in the development of radiation-induced toxicity. However, previous candidate gene association studies failed to elucidate the common genetic variation underlying this phenotype, which could emerge years after the completion of treatment. We performed a genome-wide association study on a Spanish cohort of 741 individuals with prostate cancer treated with external beam radiotherapy (EBRT). The replication cohorts consisted of 633 cases from the UK and 368 cases from North America. One locus comprising TANC1 (lowest unadjusted P value for overall late toxicity=6.85×10(-9), odds ratio (OR)=6.61, 95% confidence interval (CI)=2.23-19.63) was replicated in the second stage (lowest unadjusted P value for overall late toxicity=2.08×10(-4), OR=6.17, 95% CI=2.25-16.95; Pcombined=4.16×10(-10)). The inclusion of the third cohort gave unadjusted Pcombined=4.64×10(-11). These results, together with the role of TANC1 in regenerating damaged muscle, suggest that the TANC1 locus influences the development of late radiation-induced damage.

Among ICD recipients for secondary prevention of SCD, coronary CTO conferred a higher risk of VA recurrence and mortality in long-term follow-up. Angiographic and VA patterns could provide insights into the mechanisms of SCD and may have implications for the use of interventions designed to limit ICD shocks in this high-risk population.

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Objective: The demands of parenting are usually associated with some stress, and elevated levels of stress may affect the parent–child relationships and parenting practices. This is especially the case of families where children have special needs conditions or disorders, like Attention Deficit Hyperactivity Disorder (ADHD).Method: This study examined parenting stress among mothers of children and adolescents with ADHD. The sample comprised 126 mothers of girls (36; 29%) and boys (90; 71%) aged 6–17 years old.Results: Mothers reported their own stress levels as well as the children and adolescents’ variables (severity of their ADHD symptoms, conduct, and emotional problems) and family–contextual variables (negative impact on family’s social life, impact on couple relationship, and perceived social support). Hierarchical multiple regression showed that (a) negative impact on social life and conduct problems were the strongest predictors of mother’s stress. Bootstrap mediation analyses revealed that (b) the association between child and adolescent’s ADHD and parenting stress was mediated by children’s conduct problems and by negative impact on family’s social life, and not by children’s emotional problems nor by mother’s perceived social support. The mediation analysis also suggested (c) a pathway from child/adolescent’s ADHD through children’s conduct problems and then through their negative impact on family’s social life to mother’s parenting stress.Conclusion: These results suggest that both child/adolescent’s and family factors should be considered in the designing of interventions for reducing parenting stress in families of children and adolescents with ADHD.