The northwestern corner of South America presents a highly complex geodynamical setting including the convergence between South America, Nazca, and Caribbean plates; which also entails heterogeneity and complexity in the lithospheric structure. Here, we present depth‐migrated common‐conversion point (CCP) teleseismic receiver function profiles carried out using seismological data between 2011 and 2020 from the Colombian Geological Service, combined with some stations of observatories and international networks. These profiles provide better constraints on the lateral interpretation of the main lithospheric discontinuities in this region. We provide an updated crustal thickness map displaying some differences from previous studies, especially in the northernmost part of the cordilleran system. Our results also show some intracrustal features such as the regional detachment surface beneath the Eastern Cordillera and the presence of deep melt reservoirs under the Central Cordillera and the Paipa‐Iza complex in the Eastern Cordillera. We also discuss the lithospheric thickness and the potential existence of a highly hydrated and serpentinized mantle wedge under the forearc over the slab segment south of the Caldas tear. Furthermore, the CCP profiles further support the subduction system segmentation under northwestern South America, with at least five slab segments, two of them overlapping between ∼5.5 and ∼8°N, three belonging to the Nazca plate, and two having a Caribbean origin. The Bucaramanga nest appears to be linked to the interaction between the two northmost slab segments, while the Cauca cluster might be related to a slab dehydration process of a highly fractured zone.

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