Activated quinoline and isoquinoline undergo unexpected ring expansion by diazocarbonyl compounds via C-C insertion in the presence of 5 mol% of copper triflate to produce ethyl 1H-benzo[b]azepine-1-carboxylate and ethyl 3H-benzo[d]azepine-3-carboxylate, respectively, in excellent yields with a high degree of selectivity
Bimodal PNAs are
new PNA constructs designed to bind two different cDNA sequences synchronously
to form double duplexes. They are synthesized on solid phase using
sequential coupling and click reaction to introduce a second base
in each monomer at Cα via alkyltriazole linker. The
ternary bimodal PNA:DNA complexes show stability higher than that
of individual duplexes. Bimodal PNAs are appropriate to create higher-order
fused nucleic acid assemblies.
Peroxide-containing compounds are an attractive synthetic target, given their widespread abundance in nature, with many displaying potent antimalarial and antimicrobial properties. This review summarises the many developments in the synthesis of acyclic peroxides, with a particular focus on the past 20 years, and seeks to update organic chemists about these new approaches. The synthetic methodologies have been subdivided into metal-catalysed reactions, organocatalytic reactions, direct oxidation reactions, miscellaneous reactions and enzymatic routes to acyclic peroxides
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