Echinomycin, a DNA bis-intercalator peptide antibiotic, was complexed with γCD and loaded into PEGylated liposomes. The liposomes encapsulating echinomycin showed potent anti-proliferative and anti-invasive effect against U-87 MG glioblastoma cells.
Aim: This study investigated the effect of curcumin, from Curcuma longa, on the invasion of U87 glioma cell line spheres in 3D collagen model. Furthermore, this study investigated the anti-migration effects of curcumin on the migration of the same cell line in scratch assay.
Place and Duration of Study: Department of Pharmacology, School of Medicine, The University of Jordan, Amman, Jordan, between March 2019 and May 2019.
Methods: 3D invasion assay and 2D migration assays were used to fulfill these aims in addition to the Image J program that was used to analyze the area of invasion and the area of migration over the days of applying the assays.
Results: The results showed an inhibitory effect of curcumin in all samples tested on both the invasion and migration of U87 cell line.
Conclusion: This work adds more proofs on the importance of curcumin as anti-invasive and anti-migration agent and opens the door for more investigative studies.
Tumour dissemination is a major reason for failure of therapy for many tumour types. Metastasis and angiogenesis result from the interaction between the tumour cells in the tumour microenvironment. The detailed picture of tumour and the tumour microenvironment interaction however is not fully understood due to a lack of representative models. This review shows a brief summary of the assays and models used to describe the tumour dissemination process.
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