The Snochowice Beds rep re sent the low er most part of the Lower Ju ras sic suc ces sion in the west ern part of the Me so zoic mar gin of the Holy Cross Moun tains (Cen tral Po land). This thick, grav elly has a dif fer ent lithological char ac ter to other Lower Ju ras sic sandy and fine-grained de pos its. Eight lithofacies have been dis tin guished, mainly grav elly and sandy, grouped into four ge netic as so ci a tions: Mmas sive grav els, in ter preted as clast-rich de bris flow de pos its, G -hor i zon tally to cross-strat i fied grav els, in ter preted as grav elly bars and bedforms, S -cross-strat i fied and mas sive sand stones, in ter preted as sandy bars and bedforms and F -mas sive mudstones and claystones, gen er ally fine-grained de pos its, in ter preted as overbank de pos its. Anal y sis of depositional ge om e try and lithofacies suc cessions al lowed re con struc tion of the sed i men tary en vi ron ment: land forms of al lu vial fan type, formed mainly by braided river pro cesses and rarely by sed i ment grav ity flows. A de crease in the thick ness and con tent of grav elly lithofacies to wards the north and north-east is doc u mented. Anal y sis of trans port di rec tions has re vealed that the clastic ma te rial was trans ported to ward the north and north-east, perpen dic u lar to the main faults fring ing the ba sin. Depositional ge om e try fa cies and palaeocurrent pat terns of the Snochowice Beds in dicate that sed i men ta tion was con trolled by tec tonic ac tiv ity. Małgorzata Kozłowska, In sti tute of Ge ol ogy, Uni ver sity of War saw,
Despite significant progress in medicine, pancreatic cancer is one of the most tardily diagnosed cancer and is consequently associated with a poor prognosis and a low survival rate. The asymptomatic clinical picture and the lack of relevant diagnostic markers for the early stages of pancreatic cancer are believed to be the major constraints behind an accurate diagnosis of this disease. Furthermore, underlying mechanisms of pancreatic cancer development are still poorly recognized. It is well accepted that diabetes increases the risk of pancreatic cancer development, however the precise mechanisms are weakly investigated. Recent studies are focused on microRNAs as a causative factor of pancreatic cancer. This review aims to provide an overview of the current knowledge of pancreatic cancer and diabetes-associated microRNAs, and their potential in diagnosis and therapy. miR-96, miR-124, miR-21, and miR-10a were identified as promising biomarkers for early pancreatic cancer prediction. miR-26a, miR-101, and miR-200b carry therapeutic potential, as they not only regulate significant biological pathways, including the TGF-β and PI3K/AKT, but their re-expression contributes to the improvement of the prognosis by reducing invasiveness or chemoresistance. In diabetes, there are also changes in the expression of microRNAs, such as in miR-145, miR-29c, and miR-143. These microRNAs are involved, among others, in insulin signaling, including IRS-1 and AKT (miR-145), glucose homeostasis (hsa-miR-21), and glucose reuptake and gluconeogenesis (miR-29c). Although, changes in the expression of the same microRNAs are observed in both pancreatic cancer and diabetes, they exert different molecular effects. For example, miR-181a is upregulated in both pancreatic cancer and diabetes mellitus, but in diabetes it contributes to insulin resistance, whereas in pancreatic cancer it promotes tumor cell migration, respectively. To conclude, dysregulated microRNAs in diabetes affect crucial cellular processes that are involved in pancreatic cancer development and progression.
In flu ence of pri mary com po si tion and diagenetic min er al iza tion on nat u ral gamma-ray and den sity logs of Car bon if er ous sand stones of the Dêblin For ma tion. Geo log i cal Quar terly, 63 (4): 741-756, doi: 10.7306/gq.1498 As so ci ate ed i tor: Jacek Szczepañski The Car bon if er ous sand stone of the Dêblin For ma tion is one of the tar gets for the pe tro leum in dus try in the Lublin Ba sin in south east ern Po land. The for ma tion's pri mary and diagenetic com po si tion makes it dif fi cult to es ti mate its res er voir prop erties. Based on a de tailed anal y sis of core and petrographic sam ples, nor mal iza tion of gamma-ray and den sity logs was made with re spect to the grain-frame work of the rock. Re counted logs were used for dis tin guish ing 4 dif fer ent sand stone petrofacies. For these petrofacies, ranges of gamma-ray and bulk den sity val ues were de ter mined and the im pact of pri mary and diagenetic min eral com po si tion was es ti mated. The ap pli ca tion of this petrofacies method can up grade the level of reser voir char ac ter iza tion and sup port the in ter pre ta tion of uncored in ter vals.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.