Research ArticleABSTRACT Heat shock responsive protein HSA32 is a good candidate responsible for heat stress tolerance in crop plants. It interacts with other proteins in a signaling pathway which results its regulation of gene expression in response to heat shock. HSP101 is such protein which in combination with HSA32 is essential to thermotolerance in crop plants. In this study, we constructed 3-D structures of the two proteins. Hypothetical point mutations were also induced in HSA32 protein at amino acid position 27, 91, 159 and 220 and their 3-D models were developed. Then, protein -protein interaction was studied between two proteins. Our results showed that HSA32 and HSP101 proteins interact with each other in the active binding sites. It was also found that mutants HSA32 E
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